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- W2068520137 abstract "The present studies analyze the effect of the tervalent arsenical compound phenylarsine oxide (PAO) on hepatic response to alpha 1-adrenoreceptor stimulation. PAO, while not significantly altering the rate of glycogen breakdown, was found to inhibit many characteristic alpha 1-adrenoreceptor mediated responses including H+ and Ca2+ release, increased energy production, and vascular smooth muscle contraction. PAO inhibited basal gluconeogenesis but failed to inhibit the alpha 1-agonist induced stimulation of glucose production. These data suggest that alpha 1-adrenoreceptor mediated stimulation of metabolism and rates of ion flux across the plasma membrane are separate processes and that exchange in ion homeostasis is not essential to elicit the receptor-mediated metabolic responses. The selective effect of PAO offers an interesting tool for studying the alpha 1-adrenoreceptor signaling mechanisms." @default.
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- W2068520137 date "1995-08-01" @default.
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- W2068520137 title "Effect of phenylarsine oxide on hepatic α1-adrenoreceptor responsiveness. dissociation between ionotropic and metabolic responses" @default.
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- W2068520137 doi "https://doi.org/10.1016/0024-3205(95)02087-y" @default.
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