Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068522021> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2068522021 endingPage "541" @default.
- W2068522021 startingPage "534" @default.
- W2068522021 abstract "The antineoplastic action of bleomycin is currently thought to arise from the degradation of cellular DNA by the iron-bleomycin complex. Bleomycin A2 has one iron binding site as revealed by the iron-titrations of bleomycin monitored optically. To probe the structure of the Fe2+-bleomycin complex, we studied the paramagnetic effects of its high spin ferrous iron on the nuclear relaxation rates (1T1) of the natural abundance carbon-13 atoms in the molecule. The presence of Fe2+ in bleomycin predominantly enhances the 1T1 of only four protonated carbon atoms in the molecule (C2, C3, C5, and C6). No other protonated carbon atoms are affected significantly. From the magnitudes of the paramagnetic effects of Fe2+ on the 13C relaxation rates, we obtain distances of 3.6, 4.1, 4.0, and 3.6 Å from the metal to the C2, C3, C5, and C6 carbon atoms, respectively. These results are consistent with the metal ion-chelation of the α-amino group of the terminal diaminopropionic acid residue and the pyrimidine ring but do not implicate any other parts of the bleomycin molecule in binding to iron." @default.
- W2068522021 created "2016-06-24" @default.
- W2068522021 creator A5063346260 @default.
- W2068522021 creator A5078661649 @default.
- W2068522021 creator A5078728437 @default.
- W2068522021 date "1979-07-01" @default.
- W2068522021 modified "2023-09-25" @default.
- W2068522021 title "Location of iron in the Fe2+-bleomycin complex as observed by 13C NMR spectroscopy" @default.
- W2068522021 cites W1008982281 @default.
- W2068522021 cites W1831844194 @default.
- W2068522021 cites W1966905570 @default.
- W2068522021 cites W1999540794 @default.
- W2068522021 cites W2006422372 @default.
- W2068522021 cites W2008803918 @default.
- W2068522021 cites W2034198381 @default.
- W2068522021 cites W2038935575 @default.
- W2068522021 cites W2059420054 @default.
- W2068522021 cites W2073426822 @default.
- W2068522021 cites W2073494225 @default.
- W2068522021 cites W2074484041 @default.
- W2068522021 cites W2075249158 @default.
- W2068522021 cites W2075353344 @default.
- W2068522021 cites W2086812323 @default.
- W2068522021 cites W2115650621 @default.
- W2068522021 cites W2158927142 @default.
- W2068522021 doi "https://doi.org/10.1016/0006-291x(79)90662-4" @default.
- W2068522021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/90507" @default.
- W2068522021 hasPublicationYear "1979" @default.
- W2068522021 type Work @default.
- W2068522021 sameAs 2068522021 @default.
- W2068522021 citedByCount "17" @default.
- W2068522021 countsByYear W20685220212013 @default.
- W2068522021 crossrefType "journal-article" @default.
- W2068522021 hasAuthorship W2068522021A5063346260 @default.
- W2068522021 hasAuthorship W2068522021A5078661649 @default.
- W2068522021 hasAuthorship W2068522021A5078728437 @default.
- W2068522021 hasConcept C121332964 @default.
- W2068522021 hasConcept C124712363 @default.
- W2068522021 hasConcept C141071460 @default.
- W2068522021 hasConcept C145148216 @default.
- W2068522021 hasConcept C178790620 @default.
- W2068522021 hasConcept C179104552 @default.
- W2068522021 hasConcept C185592680 @default.
- W2068522021 hasConcept C197404232 @default.
- W2068522021 hasConcept C2775832776 @default.
- W2068522021 hasConcept C2776232574 @default.
- W2068522021 hasConcept C2776694085 @default.
- W2068522021 hasConcept C2779321679 @default.
- W2068522021 hasConcept C30095370 @default.
- W2068522021 hasConcept C32909587 @default.
- W2068522021 hasConcept C544153396 @default.
- W2068522021 hasConcept C62520636 @default.
- W2068522021 hasConcept C66974803 @default.
- W2068522021 hasConcept C71240020 @default.
- W2068522021 hasConcept C71924100 @default.
- W2068522021 hasConcept C75473681 @default.
- W2068522021 hasConcept C8010536 @default.
- W2068522021 hasConceptScore W2068522021C121332964 @default.
- W2068522021 hasConceptScore W2068522021C124712363 @default.
- W2068522021 hasConceptScore W2068522021C141071460 @default.
- W2068522021 hasConceptScore W2068522021C145148216 @default.
- W2068522021 hasConceptScore W2068522021C178790620 @default.
- W2068522021 hasConceptScore W2068522021C179104552 @default.
- W2068522021 hasConceptScore W2068522021C185592680 @default.
- W2068522021 hasConceptScore W2068522021C197404232 @default.
- W2068522021 hasConceptScore W2068522021C2775832776 @default.
- W2068522021 hasConceptScore W2068522021C2776232574 @default.
- W2068522021 hasConceptScore W2068522021C2776694085 @default.
- W2068522021 hasConceptScore W2068522021C2779321679 @default.
- W2068522021 hasConceptScore W2068522021C30095370 @default.
- W2068522021 hasConceptScore W2068522021C32909587 @default.
- W2068522021 hasConceptScore W2068522021C544153396 @default.
- W2068522021 hasConceptScore W2068522021C62520636 @default.
- W2068522021 hasConceptScore W2068522021C66974803 @default.
- W2068522021 hasConceptScore W2068522021C71240020 @default.
- W2068522021 hasConceptScore W2068522021C71924100 @default.
- W2068522021 hasConceptScore W2068522021C75473681 @default.
- W2068522021 hasConceptScore W2068522021C8010536 @default.
- W2068522021 hasIssue "2" @default.
- W2068522021 hasLocation W20685220211 @default.
- W2068522021 hasLocation W20685220212 @default.
- W2068522021 hasOpenAccess W2068522021 @default.
- W2068522021 hasPrimaryLocation W20685220211 @default.
- W2068522021 hasRelatedWork W1972518367 @default.
- W2068522021 hasRelatedWork W1987857812 @default.
- W2068522021 hasRelatedWork W2003986763 @default.
- W2068522021 hasRelatedWork W2031936708 @default.
- W2068522021 hasRelatedWork W2037971223 @default.
- W2068522021 hasRelatedWork W2048136026 @default.
- W2068522021 hasRelatedWork W2141054631 @default.
- W2068522021 hasRelatedWork W2321039488 @default.
- W2068522021 hasRelatedWork W2950743036 @default.
- W2068522021 hasRelatedWork W2103368290 @default.
- W2068522021 hasVolume "89" @default.
- W2068522021 isParatext "false" @default.
- W2068522021 isRetracted "false" @default.
- W2068522021 magId "2068522021" @default.
- W2068522021 workType "article" @default.