Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068528056> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2068528056 endingPage "35" @default.
- W2068528056 startingPage "23" @default.
- W2068528056 abstract "Pentachlorophenol (PCP) is an inhibitor of phenol-sulfotransferases and has been used to ascertain the role of sulfation in toxicology. Recently, molybdate has been shown to inhibit the sulfation of various chemicals by decreasing hepatic concentrations of the cosubstrate, 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The purpose of this study was to compare the effectiveness of these two chemicals in inhibiting the sulfation of various doses of acetaminophen (AA) in the rat. PCP (40 micromol/kg) decreased the 2-h combined biliary and urinary excretion of AA-sulfate by 78, 83, 84, and 47% of the 0.1, 0.3, 1, and 3 mmol/kg doses of AA, respectively. Molybdate (7.5 mmol/kg) decreased the sulfation of these same doses of AA by 50, 65, 62, and 81%, respectively. These data indicate that PCP is more effective in decreasing the sulfation of low than high doses of AA, which may result from less AA, at lower doses, to compete with PCP for sulfotransferases. Conversely, molybdate is more effective in decreasing sulfation of high rather than low doses of AA because molybdate decreases sulfate availability and decreases PAPS synthesis. More PAPS is required for the sulfation of high than low doses of AA. Therefore, PCP inhibits sulfation more effectively at low doses of AA when sulfation is limited by sulfotransferases, and molybdate inhibits sulfation more effectively at high doses of AA when sulfation is limited by PAPS." @default.
- W2068528056 created "2016-06-24" @default.
- W2068528056 creator A5043369055 @default.
- W2068528056 creator A5076743166 @default.
- W2068528056 date "2000-04-01" @default.
- W2068528056 modified "2023-10-18" @default.
- W2068528056 title "Effects of molybdate and pentachlorophenol on the sulfation of acetaminophen" @default.
- W2068528056 cites W1480705316 @default.
- W2068528056 cites W1589803734 @default.
- W2068528056 cites W1600973584 @default.
- W2068528056 cites W1997609371 @default.
- W2068528056 cites W2013622249 @default.
- W2068528056 cites W2018206204 @default.
- W2068528056 cites W2047602017 @default.
- W2068528056 cites W2117354924 @default.
- W2068528056 cites W2144109917 @default.
- W2068528056 cites W2149820996 @default.
- W2068528056 cites W2318909204 @default.
- W2068528056 cites W2327301431 @default.
- W2068528056 cites W2344120695 @default.
- W2068528056 cites W55990787 @default.
- W2068528056 doi "https://doi.org/10.1016/s0300-483x(00)00159-1" @default.
- W2068528056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10773360" @default.
- W2068528056 hasPublicationYear "2000" @default.
- W2068528056 type Work @default.
- W2068528056 sameAs 2068528056 @default.
- W2068528056 citedByCount "9" @default.
- W2068528056 countsByYear W20685280562012 @default.
- W2068528056 countsByYear W20685280562015 @default.
- W2068528056 countsByYear W20685280562017 @default.
- W2068528056 countsByYear W20685280562018 @default.
- W2068528056 crossrefType "journal-article" @default.
- W2068528056 hasAuthorship W2068528056A5043369055 @default.
- W2068528056 hasAuthorship W2068528056A5076743166 @default.
- W2068528056 hasConcept C155138218 @default.
- W2068528056 hasConcept C178790620 @default.
- W2068528056 hasConcept C179104552 @default.
- W2068528056 hasConcept C185592680 @default.
- W2068528056 hasConcept C2775904581 @default.
- W2068528056 hasConcept C2775981058 @default.
- W2068528056 hasConcept C2778343803 @default.
- W2068528056 hasConcept C2779912340 @default.
- W2068528056 hasConcept C55493867 @default.
- W2068528056 hasConceptScore W2068528056C155138218 @default.
- W2068528056 hasConceptScore W2068528056C178790620 @default.
- W2068528056 hasConceptScore W2068528056C179104552 @default.
- W2068528056 hasConceptScore W2068528056C185592680 @default.
- W2068528056 hasConceptScore W2068528056C2775904581 @default.
- W2068528056 hasConceptScore W2068528056C2775981058 @default.
- W2068528056 hasConceptScore W2068528056C2778343803 @default.
- W2068528056 hasConceptScore W2068528056C2779912340 @default.
- W2068528056 hasConceptScore W2068528056C55493867 @default.
- W2068528056 hasIssue "1" @default.
- W2068528056 hasLocation W20685280561 @default.
- W2068528056 hasLocation W20685280562 @default.
- W2068528056 hasOpenAccess W2068528056 @default.
- W2068528056 hasPrimaryLocation W20685280561 @default.
- W2068528056 hasRelatedWork W1991331363 @default.
- W2068528056 hasRelatedWork W2000309406 @default.
- W2068528056 hasRelatedWork W2012632422 @default.
- W2068528056 hasRelatedWork W2038144906 @default.
- W2068528056 hasRelatedWork W2047602017 @default.
- W2068528056 hasRelatedWork W2063679949 @default.
- W2068528056 hasRelatedWork W2068528056 @default.
- W2068528056 hasRelatedWork W2080102128 @default.
- W2068528056 hasRelatedWork W2097230678 @default.
- W2068528056 hasRelatedWork W2140472745 @default.
- W2068528056 hasVolume "146" @default.
- W2068528056 isParatext "false" @default.
- W2068528056 isRetracted "false" @default.
- W2068528056 magId "2068528056" @default.
- W2068528056 workType "article" @default.