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• W2068528366 abstract "Aiming to develop a new 99mTc-labeled folate derivative for FR-positive tumor imaging, a simpler method has been established to synthesize the folate-drug conjugates with free α-carboxyl group. In this study, the conjugate pteroyl-lys-HYNIC was synthesized and labeled with 99mTc using tricine and TPPTS as co-ligands. The radiochemical purity of the final complex 99mTc(HYNIC-lys-pteroyl)(tricine/TPPTS), 5 was high (>98%), and it remained stable in saline and plasma over 6 h after preparation. The biologic evaluation results showed that the 99mTc labeled pteroyl-lys conjugate was able to specifically target the FR-positive tumor cells and tissues both in vitro and in vivo, highlighting its potential as an effective folate receptor targeted agent for tumor imaging." @default.
• W2068528366 created "2016-06-24" @default.
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• W2068528366 date "2011-04-01" @default.
• W2068528366 modified "2023-10-09" @default.
• W2068528366 title "The synthesis of pteroyl-lys conjugates and its application as Technetium-99m labeled radiotracer for folate receptor-positive tumor targeting" @default.
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• W2068528366 doi "https://doi.org/10.1016/j.bmcl.2011.02.014" @default.
• W2068528366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21377880" @default.
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