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- W2068537002 abstract "HIV-1 drug resistance is a result of mutations occurring within the wild-type viral genome that produce variants capable of efficiently replication in the presence of antiretroviral agents. The first report of HIV-1 drug resistance was to zidovudine (ZDV) in 1989 [1]. Subsequently drug resistance to all therapeutic antiretroviral agents has been observed (for a review see [2]) Although highly active antiretroviral therapy for the treatment of HIV-1 infection has produced substantial decreases in morbidity and mortality in recent years [34] (for a review see [5]) as many of 50% of patients fail therapy within 1 year of initiation [6]. As drug-resistant HIV-1 variants are often selected during the course of antiretroviral therapy [2] drug resistance is considered a major contributor to treatment failure. Furthermore cross-resistance has a considerable negative impact on future treatment options. To address this current consensus guidelines recommend the use of HIV-1 drug resistance testing as a clinical management tool to help guide the choice of new regimens particularly after treatment failure and for guiding therapy for pregnant women [78]. The high rate of treatment failure due to the evolution of drug resistance mutations makes the development of new drugs that are active against resistant variants of paramount importance. (excerpt)" @default.
- W2068537002 created "2016-06-24" @default.
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- W2068537002 date "2001-01-01" @default.
- W2068537002 modified "2023-09-26" @default.
- W2068537002 title "Mechanisms of HIV-1 drug resistance" @default.
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- W2068537002 doi "https://doi.org/10.1097/00002030-200100005-00005" @default.
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