Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068539984> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2068539984 endingPage "147" @default.
- W2068539984 startingPage "141" @default.
- W2068539984 abstract "In this work, we investigated the concentration effects on the encapsulation of prilocaine (PLC), an aminoamide local anesthetic, into a small unilamellar liposome, at physiological pH. On the line of our previous work, we have carried out Molecular Dynamics (MD) simulations using a coarse grain (CG) model that allow us to reach the microsecond time scale. At physiological pH there is a partition between protonated and neutral PLCs. In order to estimate the protonated/neutral PLC ratio at physiological pH (7.4), we have used the Henderson-Hasselbach equation. We have studied three PLC:lipid molar concentrations, ranging between 10:10 to 1:4. We essentially found that all neutral PLC molecules rapidly diffuse into the hydrophobic region of the vesicle adopting an asymmetric bimodal distribution. Moreover, protonated PLC molecules partition between the external monolayer of the vesicle and the water phase, having a high rate of exchange between this two phases, with no access to the inner part of the liposome in a concentration dependent way. In this way, we found that the behavior of PLCs at physiological pH is a combination of high and low pH, especially at low concentration of local anesthetics." @default.
- W2068539984 created "2016-06-24" @default.
- W2068539984 creator A5050843725 @default.
- W2068539984 creator A5073437769 @default.
- W2068539984 creator A5076758176 @default.
- W2068539984 date "2013-02-01" @default.
- W2068539984 modified "2023-10-16" @default.
- W2068539984 title "Molecular Dynamics Study on the Encapsulation of Prilocaine in Liposomes at Physiological pH" @default.
- W2068539984 cites W1502116701 @default.
- W2068539984 cites W1966078827 @default.
- W2068539984 cites W1973374160 @default.
- W2068539984 cites W1977105620 @default.
- W2068539984 cites W1988925907 @default.
- W2068539984 cites W1989144616 @default.
- W2068539984 cites W1993063667 @default.
- W2068539984 cites W1998966261 @default.
- W2068539984 cites W2015178572 @default.
- W2068539984 cites W2017755743 @default.
- W2068539984 cites W2043944565 @default.
- W2068539984 cites W2045546935 @default.
- W2068539984 cites W2053047880 @default.
- W2068539984 cites W2058045291 @default.
- W2068539984 cites W2070246190 @default.
- W2068539984 cites W2074433907 @default.
- W2068539984 cites W2077455410 @default.
- W2068539984 cites W2080951158 @default.
- W2068539984 cites W2083733356 @default.
- W2068539984 cites W2086363028 @default.
- W2068539984 cites W2097563477 @default.
- W2068539984 cites W2112608243 @default.
- W2068539984 cites W2114132390 @default.
- W2068539984 cites W2118385231 @default.
- W2068539984 cites W2119267663 @default.
- W2068539984 cites W2119784812 @default.
- W2068539984 cites W2137565699 @default.
- W2068539984 cites W2143823923 @default.
- W2068539984 cites W2144791518 @default.
- W2068539984 cites W2153590115 @default.
- W2068539984 cites W2167165619 @default.
- W2068539984 doi "https://doi.org/10.1166/jbt.2013.1074" @default.
- W2068539984 hasPublicationYear "2013" @default.
- W2068539984 type Work @default.
- W2068539984 sameAs 2068539984 @default.
- W2068539984 citedByCount "3" @default.
- W2068539984 countsByYear W20685399842017 @default.
- W2068539984 countsByYear W20685399842018 @default.
- W2068539984 countsByYear W20685399842020 @default.
- W2068539984 crossrefType "journal-article" @default.
- W2068539984 hasAuthorship W2068539984A5050843725 @default.
- W2068539984 hasAuthorship W2068539984A5073437769 @default.
- W2068539984 hasAuthorship W2068539984A5076758176 @default.
- W2068539984 hasConcept C12554922 @default.
- W2068539984 hasConcept C185154212 @default.
- W2068539984 hasConcept C185592680 @default.
- W2068539984 hasConcept C2778994108 @default.
- W2068539984 hasConcept C2780560023 @default.
- W2068539984 hasConcept C31258907 @default.
- W2068539984 hasConcept C41008148 @default.
- W2068539984 hasConcept C42219234 @default.
- W2068539984 hasConcept C55493867 @default.
- W2068539984 hasConcept C71924100 @default.
- W2068539984 hasConcept C81147070 @default.
- W2068539984 hasConcept C86803240 @default.
- W2068539984 hasConcept C98274493 @default.
- W2068539984 hasConceptScore W2068539984C12554922 @default.
- W2068539984 hasConceptScore W2068539984C185154212 @default.
- W2068539984 hasConceptScore W2068539984C185592680 @default.
- W2068539984 hasConceptScore W2068539984C2778994108 @default.
- W2068539984 hasConceptScore W2068539984C2780560023 @default.
- W2068539984 hasConceptScore W2068539984C31258907 @default.
- W2068539984 hasConceptScore W2068539984C41008148 @default.
- W2068539984 hasConceptScore W2068539984C42219234 @default.
- W2068539984 hasConceptScore W2068539984C55493867 @default.
- W2068539984 hasConceptScore W2068539984C71924100 @default.
- W2068539984 hasConceptScore W2068539984C81147070 @default.
- W2068539984 hasConceptScore W2068539984C86803240 @default.
- W2068539984 hasConceptScore W2068539984C98274493 @default.
- W2068539984 hasIssue "1" @default.
- W2068539984 hasLocation W20685399841 @default.
- W2068539984 hasOpenAccess W2068539984 @default.
- W2068539984 hasPrimaryLocation W20685399841 @default.
- W2068539984 hasRelatedWork W1974938772 @default.
- W2068539984 hasRelatedWork W2030063071 @default.
- W2068539984 hasRelatedWork W2038782216 @default.
- W2068539984 hasRelatedWork W2121486516 @default.
- W2068539984 hasRelatedWork W2169309865 @default.
- W2068539984 hasRelatedWork W2505365810 @default.
- W2068539984 hasRelatedWork W2982737140 @default.
- W2068539984 hasRelatedWork W4245912757 @default.
- W2068539984 hasRelatedWork W4307591494 @default.
- W2068539984 hasRelatedWork W2183136778 @default.
- W2068539984 hasVolume "3" @default.
- W2068539984 isParatext "false" @default.
- W2068539984 isRetracted "false" @default.
- W2068539984 magId "2068539984" @default.
- W2068539984 workType "article" @default.