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• W2068540935 abstract "The three imidazole antimycotics clotrimazole, miconazole, and ketoconazole all inhibit the demethylation of lanosterol to ergosterol, resulting in inhibition of growth of Saccharomyces cerevisiae; this is a fungistatic action. At higher concentrations clotrimazole and miconazole are fungicidal, whereas ketoconazole is not. The fungicidal action reflects direct membrane damage by the imidazoles. Evidence for this is that ketoconazole is markedly less active than the other imidazoles in its ability to allow methylene blue entry into cells and to disrupt liposome model membranes. The possible clinical significance of these findings is discussed." @default.
• W2068540935 created "2016-06-24" @default.
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• W2068540935 date "1981-07-01" @default.
• W2068540935 modified "2023-10-14" @default.
• W2068540935 title "Heterogeneity of action of mechanisms among antimycotic imidazoles" @default.
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• W2068540935 doi "https://doi.org/10.1128/aac.20.1.71" @default.
• W2068540935 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/181635" @default.
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