FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068542212> ?p ?o ?g. }

• W2068542212 endingPage "330" @default.
• W2068542212 startingPage "324" @default.
• W2068542212 abstract "In 2007, the U.S. National Academy of Sciences released a report, Toxicity Testing in the 21st Century: A Vision and a Strategy, that envisions a not-so-distant future in which virtually all routine toxicity testing would be conducted in human cells or cell lines in vitro by evaluating cellular responses in a suite of toxicity pathway assays using high-throughput tests, that could be implemented with robotic assistance. Risk assessment based on results of these types of tests would shift towards the avoidance of significant perturbations of these pathways in exposed human populations. Dose-response modeling of perturbations of pathway function would be organized around computational systems biology models of the circuitry underlying each toxicity pathway. In vitro to in vivo extrapolations would rely on pharmacokinetic models to predict human blood and tissue concentrations under specific exposure conditions. All of the scientific tools needed to affect these changes in toxicity testing practices are either currently available or in an advanced state of development. A broad scientific discussion of this new vision for the future of toxicity testing is needed to motivate a departure from the traditional high dose animal-based toxicological tests, with its attendant challenges for dose and species extrapolation, towards a new approach more firmly grounded in human biology. The present paper, and invited commentaries on the report that will appear in Toxicological Sciences over the next year, are intended to initiate a dialog to identify challenges in implementing the vision and address obstacles to change." @default.
• W2068542212 created "2016-06-24" @default.
• W2068542212 creator A5026001980 @default.
• W2068542212 creator A5078135654 @default.
• W2068542212 date "2008-12-12" @default.
• W2068542212 modified "2023-10-01" @default.
• W2068542212 title "Toxicity Testing in the 21st Century: Bringing the Vision to Life" @default.
• W2068542212 cites W1265362402 @default.
• W2068542212 cites W1566175382 @default.
• W2068542212 cites W1579194856 @default.
• W2068542212 cites W1972687225 @default.
• W2068542212 cites W1985911638 @default.
• W2068542212 cites W1991820123 @default.
• W2068542212 cites W2001110181 @default.
• W2068542212 cites W2007165568 @default.
• W2068542212 cites W2010031978 @default.
• W2068542212 cites W2011450783 @default.
• W2068542212 cites W2061425021 @default.
• W2068542212 cites W2065915163 @default.
• W2068542212 cites W2079870118 @default.
• W2068542212 cites W2081659180 @default.
• W2068542212 cites W2087248274 @default.
• W2068542212 cites W2098925346 @default.
• W2068542212 cites W2122025333 @default.
• W2068542212 cites W2125987139 @default.
• W2068542212 cites W2128879247 @default.
• W2068542212 cites W2138977668 @default.
• W2068542212 cites W2165438231 @default.
• W2068542212 cites W2245542383 @default.
• W2068542212 doi "https://doi.org/10.1093/toxsci/kfn255" @default.
• W2068542212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19074763" @default.
• W2068542212 hasPublicationYear "2008" @default.
• W2068542212 type Work @default.
• W2068542212 sameAs 2068542212 @default.
• W2068542212 citedByCount "280" @default.
• W2068542212 countsByYear W20685422122012 @default.
• W2068542212 countsByYear W20685422122013 @default.
• W2068542212 countsByYear W20685422122014 @default.
• W2068542212 countsByYear W20685422122015 @default.
• W2068542212 countsByYear W20685422122016 @default.
• W2068542212 countsByYear W20685422122017 @default.
• W2068542212 countsByYear W20685422122018 @default.
• W2068542212 countsByYear W20685422122019 @default.
• W2068542212 countsByYear W20685422122020 @default.
• W2068542212 countsByYear W20685422122021 @default.
• W2068542212 countsByYear W20685422122022 @default.
• W2068542212 countsByYear W20685422122023 @default.
• W2068542212 crossrefType "journal-article" @default.
• W2068542212 hasAuthorship W2068542212A5026001980 @default.
• W2068542212 hasAuthorship W2068542212A5078135654 @default.
• W2068542212 hasBestOaLocation W20685422121 @default.
• W2068542212 hasConcept C12174686 @default.
• W2068542212 hasConcept C126322002 @default.
• W2068542212 hasConcept C136764020 @default.
• W2068542212 hasConcept C14036430 @default.
• W2068542212 hasConcept C173853756 @default.
• W2068542212 hasConcept C188598960 @default.
• W2068542212 hasConcept C199360897 @default.
• W2068542212 hasConcept C2777904410 @default.
• W2068542212 hasConcept C29730261 @default.
• W2068542212 hasConcept C33070731 @default.
• W2068542212 hasConcept C38652104 @default.
• W2068542212 hasConcept C41008148 @default.
• W2068542212 hasConcept C520753416 @default.
• W2068542212 hasConcept C54355233 @default.
• W2068542212 hasConcept C70721500 @default.
• W2068542212 hasConcept C71924100 @default.
• W2068542212 hasConcept C86803240 @default.
• W2068542212 hasConceptScore W2068542212C12174686 @default.
• W2068542212 hasConceptScore W2068542212C126322002 @default.
• W2068542212 hasConceptScore W2068542212C136764020 @default.
• W2068542212 hasConceptScore W2068542212C14036430 @default.
• W2068542212 hasConceptScore W2068542212C173853756 @default.
• W2068542212 hasConceptScore W2068542212C188598960 @default.
• W2068542212 hasConceptScore W2068542212C199360897 @default.
• W2068542212 hasConceptScore W2068542212C2777904410 @default.
• W2068542212 hasConceptScore W2068542212C29730261 @default.
• W2068542212 hasConceptScore W2068542212C33070731 @default.
• W2068542212 hasConceptScore W2068542212C38652104 @default.
• W2068542212 hasConceptScore W2068542212C41008148 @default.
• W2068542212 hasConceptScore W2068542212C520753416 @default.
• W2068542212 hasConceptScore W2068542212C54355233 @default.
• W2068542212 hasConceptScore W2068542212C70721500 @default.
• W2068542212 hasConceptScore W2068542212C71924100 @default.
• W2068542212 hasConceptScore W2068542212C86803240 @default.
• W2068542212 hasIssue "2" @default.
• W2068542212 hasLocation W20685422121 @default.
• W2068542212 hasLocation W20685422122 @default.
• W2068542212 hasOpenAccess W2068542212 @default.
• W2068542212 hasPrimaryLocation W20685422121 @default.
• W2068542212 hasRelatedWork W1561318938 @default.
• W2068542212 hasRelatedWork W1570813436 @default.
• W2068542212 hasRelatedWork W1862650538 @default.
• W2068542212 hasRelatedWork W2144314211 @default.
• W2068542212 hasRelatedWork W2352008582 @default.
• W2068542212 hasRelatedWork W2377424484 @default.
• W2068542212 hasRelatedWork W2380245606 @default.
• W2068542212 hasRelatedWork W2388455477 @default.

• next