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- W2068551418 abstract "The study of trabectedin in the treatment of patients with soft-tissue sarcoma by Nicolas Penel and colleagues 1 Le Cesne A Blay J-Y Domont J et al. Interruption versus continuation of trabectedin in patients with soft-tissue sarcoma (T-DIS): a randomised phase 2 trial. Lancet Oncol. 2015; 16: 312-319 Summary Full Text Full Text PDF PubMed Scopus (72) Google Scholar presented in The Lancet Oncology brings up many topics for discussion in chemotherapy development and sarcoma research. Discovered during the phenotypic screening of plant and marine organic compounds in the 1960s, ET-743 or trabectedin was first isolated in an extract from the sea squirt Ecteinascidia turbinata. Although it took until 1996 for the marine alkaloid to be synthetically produced and given to patients, trabectedin remains a poster child for empirically based drug discovery. 2 Jimeno J Lopez-Martin JA Ruiz-Casado A et al. Progress in the clinical development of new marine-derived anticancer compounds. Anticancer Drugs. 2004; 15: 321-329 Crossref PubMed Scopus (82) Google Scholar Interruption versus continuation of trabectedin in patients with soft-tissue sarcoma (T-DIS): a randomised phase 2 trialWe do not recommend trabectedin discontinuation in patients with advanced, doxorubicin-refractory soft-tissue sarcoma who have not progressed after six cycles of treatment. Full-Text PDF" @default.
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- W2068551418 date "2015-03-01" @default.
- W2068551418 modified "2023-09-27" @default.
- W2068551418 title "Trabectedin tactics: from sea squirts to sarcomas" @default.
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- W2068551418 doi "https://doi.org/10.1016/s1470-2045(15)70062-8" @default.
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