FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068556317> ?p ?o ?g. }

• W2068556317 endingPage "7069" @default.
• W2068556317 startingPage "7063" @default.
• W2068556317 abstract "Abstract Langerhans cells (LCs) are a distinct population of dendritic cells that form a contiguous network in the epidermis of the skin. Although LCs possess many of the properties of highly proficient dendritic cells, recent studies have indicated that they are not necessary to initiate cutaneous immunity. In this study, we used a tractable model of cutaneous GVHD, induced by topical application of a Toll-like receptor agonist, to explore the role of LCs in the development of tissue injury. By adapting this model to permit inducible and selective depletion of host LCs, we found that GVHD was significantly reduced when LCs were absent. However, LCs were not required either for CD8 T-cell activation within the draining lymph node or subsequent homing of effector cells to the epidermis. Instead, we found that LCs were necessary for inducing transcription of IFN-γ and other key effector molecules by donor CD8 cells in the epidermis, indicating that they license CD8 cells to induce epithelial injury. These data demonstrate a novel regulatory role for epidermal LCs during the effector phase of an inflammatory immune response in the skin." @default.
• W2068556317 created "2016-06-24" @default.
• W2068556317 creator A5000660098 @default.
• W2068556317 creator A5007162906 @default.
• W2068556317 creator A5007240984 @default.
• W2068556317 creator A5008878313 @default.
• W2068556317 creator A5022411341 @default.
• W2068556317 creator A5026879347 @default.
• W2068556317 creator A5042917669 @default.
• W2068556317 creator A5059241062 @default.
• W2068556317 creator A5073023097 @default.
• W2068556317 creator A5085234051 @default.
• W2068556317 date "2011-06-30" @default.
• W2068556317 modified "2023-10-11" @default.
• W2068556317 title "Langerhans cells regulate cutaneous injury by licensing CD8 effector cells recruited to the skin" @default.
• W2068556317 cites W1585761689 @default.
• W2068556317 cites W1978568541 @default.
• W2068556317 cites W1979185708 @default.
• W2068556317 cites W1981195980 @default.
• W2068556317 cites W1982916524 @default.
• W2068556317 cites W1984275656 @default.
• W2068556317 cites W1994328363 @default.
• W2068556317 cites W1998844140 @default.
• W2068556317 cites W2000779524 @default.
• W2068556317 cites W2012660279 @default.
• W2068556317 cites W2017060956 @default.
• W2068556317 cites W2018733478 @default.
• W2068556317 cites W2035820003 @default.
• W2068556317 cites W2053601970 @default.
• W2068556317 cites W2064464816 @default.
• W2068556317 cites W2074673603 @default.
• W2068556317 cites W2076397065 @default.
• W2068556317 cites W2078710631 @default.
• W2068556317 cites W2078927542 @default.
• W2068556317 cites W2087975832 @default.
• W2068556317 cites W2097730151 @default.
• W2068556317 cites W2099260174 @default.
• W2068556317 cites W2104399805 @default.
• W2068556317 cites W2114269157 @default.
• W2068556317 cites W2117626573 @default.
• W2068556317 cites W2124325544 @default.
• W2068556317 cites W2131746171 @default.
• W2068556317 cites W2131878781 @default.
• W2068556317 cites W2150897631 @default.
• W2068556317 cites W2150959582 @default.
• W2068556317 cites W2154137408 @default.
• W2068556317 cites W2155063004 @default.
• W2068556317 cites W2156489752 @default.
• W2068556317 cites W2163008986 @default.
• W2068556317 cites W2169192341 @default.
• W2068556317 doi "https://doi.org/10.1182/blood-2011-01-329185" @default.
• W2068556317 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3336775" @default.
• W2068556317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21566096" @default.
• W2068556317 hasPublicationYear "2011" @default.
• W2068556317 type Work @default.
• W2068556317 sameAs 2068556317 @default.
• W2068556317 citedByCount "38" @default.
• W2068556317 countsByYear W20685563172012 @default.
• W2068556317 countsByYear W20685563172013 @default.
• W2068556317 countsByYear W20685563172014 @default.
• W2068556317 countsByYear W20685563172015 @default.
• W2068556317 countsByYear W20685563172016 @default.
• W2068556317 countsByYear W20685563172017 @default.
• W2068556317 countsByYear W20685563172018 @default.
• W2068556317 countsByYear W20685563172020 @default.
• W2068556317 countsByYear W20685563172021 @default.
• W2068556317 countsByYear W20685563172022 @default.
• W2068556317 crossrefType "journal-article" @default.
• W2068556317 hasAuthorship W2068556317A5000660098 @default.
• W2068556317 hasAuthorship W2068556317A5007162906 @default.
• W2068556317 hasAuthorship W2068556317A5007240984 @default.
• W2068556317 hasAuthorship W2068556317A5008878313 @default.
• W2068556317 hasAuthorship W2068556317A5022411341 @default.
• W2068556317 hasAuthorship W2068556317A5026879347 @default.
• W2068556317 hasAuthorship W2068556317A5042917669 @default.
• W2068556317 hasAuthorship W2068556317A5059241062 @default.
• W2068556317 hasAuthorship W2068556317A5073023097 @default.
• W2068556317 hasAuthorship W2068556317A5085234051 @default.
• W2068556317 hasBestOaLocation W20685563171 @default.
• W2068556317 hasConcept C105702510 @default.
• W2068556317 hasConcept C151872237 @default.
• W2068556317 hasConcept C154317977 @default.
• W2068556317 hasConcept C167672396 @default.
• W2068556317 hasConcept C18903297 @default.
• W2068556317 hasConcept C202751555 @default.
• W2068556317 hasConcept C203014093 @default.
• W2068556317 hasConcept C2776458125 @default.
• W2068556317 hasConcept C2778170410 @default.
• W2068556317 hasConcept C2908647359 @default.
• W2068556317 hasConcept C51785407 @default.
• W2068556317 hasConcept C55493867 @default.
• W2068556317 hasConcept C71924100 @default.
• W2068556317 hasConcept C86803240 @default.
• W2068556317 hasConcept C8891405 @default.
• W2068556317 hasConcept C95444343 @default.
• W2068556317 hasConcept C99454951 @default.
• W2068556317 hasConceptScore W2068556317C105702510 @default.
• W2068556317 hasConceptScore W2068556317C151872237 @default.

• next