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- W2068557675 abstract "Activated protein C (APC) promotes angiogenesis and reepithelialisation and accelerates healing of diabetic ulcers. The aim of this study was to determine the relationship between the incidence of lower leg ulcers and plasma levels of APC's precursor, protein C (PC), in diabetic patients. Patients with diabetes who had a lower leg ulcer(s) for >6 months (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>36</mml:mn></mml:mrow></mml:math>) were compared with age-, type of diabetes-, and sex-matched subjects with diabetes but without an ulcer (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>36</mml:mn></mml:mrow></mml:math>, controls). Total PC was assessed using a routine PC colorimetric assay. There was a significantly (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:mrow></mml:math>) lower level of plasma PC in patients with ulcers (103.3 ± 22.7, mean ± SD) compared with control (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:mn>127.1</mml:mn><mml:mo>±</mml:mo><mml:mn>34.0</mml:mn></mml:mrow></mml:math>) subjects, when corrected for age and matched for gender and type of diabetes. Ulcer type (neuropathic, ischaemic, or mixed) was not a significant covariate for plasma PC levels (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.35</mml:mn></mml:mrow></mml:math>). There was no correlation between PC levels and gender, type of diabetes,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mrow><mml:msub><mml:mrow><mml:mtext>HbA</mml:mtext></mml:mrow><mml:mrow><mml:mn mathvariant=normal>1</mml:mn><mml:mtext>c</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:math>, or C-reactive protein in either group. In summary, decreased circulating PC levels are associated with, and may predispose to, lower leg ulceration in patients with diabetes." @default.
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- W2068557675 date "2013-01-01" @default.
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- W2068557675 title "Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes" @default.
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- W2068557675 doi "https://doi.org/10.1155/2013/719570" @default.
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