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• W2068558742 abstract "A meta-analysis was performed to assess the association of C47T (rs4880) (also called Val16Ala) polymorphism in SOD2 gene with reduced risk of diabetes mellitus, including type 1 and type 2 diabetes, and diabetic microvascular complications (DMI) including diabetic nephropathy, diabetic retinopathy and diabetic polyneuropathy. A comprehensive search was conducted to identify all case–control or cohort design studies of the above-mentioned associations. The fixed or random effect pooled measure was selected on the basis of homogeneity test among studies. Heterogeneity among studies was evaluated using the I 2. Meta-regression and the ‘leave one out’ sensitive analysis of Patsopoulos et al. were used to explore potential sources of between-study heterogeneity. Publication bias was estimated using modified Egger’s linear regression test as proposed by Harbord et al. Seventeen articles were included. After excluding articles that deviated from Hardy–Weinberg equilibrium in cases and/or in controls, and were also the key contributors to between-study heterogeneity, the meta-analysis showed a significant association of the C allele with reduced risk of DMI in dominant (OR 0.788, 95% CI 0.680–0.914), recessive (OR 0.808, 95% CI 0.685–0.953) and codominant (OR 0.828, 95% CI 0.751–0.913) models. It also showed a significant association with reduced risk of diabetic nephropathy in the dominant model (OR 0.801, 95% CI 0.664–0.967), and reduced risk of diabetic retinopathy in the dominant (OR 0.601, 95% CI 0.423–0.855), recessive (OR 0.548, 95% CI 0.369–0.814) and codominant (OR 0.651, 95% CI 0.517–0.820) models. The meta-analysis suggested that C allele of C47T polymorphism in SOD2 gene has protective effects on risk of DMI, diabetic nephropathy and diabetic retinopathy. This risk needs to be confirmed by further studies." @default.
• W2068558742 created "2016-06-24" @default.
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• W2068558742 date "2010-12-22" @default.
• W2068558742 modified "2023-09-26" @default.
• W2068558742 title "Association of the C47T polymorphism in SOD2 with diabetes mellitus and diabetic microvascular complications: a meta-analysis" @default.
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• W2068558742 doi "https://doi.org/10.1007/s00125-010-2004-5" @default.
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