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• W2068561263 abstract "Abstract Objectives A multicentre prospective non‐randomised study of de novo acute myeloid leukaemia ( AML ) in patients aged ≥70 yr was designed to reduce toxicity and achieve acceptable complete remission ( CR ) rates. Methods The outpatient treatment included induction with oral fludarabine, subcutaneous cytarabine and subcutaneous filgrastim ( FAG ). The patients received more induction cycles according to the response achieved. If there was no response to induction with FAG , the following induction cycle included oral idarubicin, subcutaneous cytarabine and subcutaneous filgrastim ( IAG ). Patients achieving CR received one intensification ( FAG on response to previous FAG or alternatively IAG ) and one consolidation cycle ( IAG ). Results Thirty patients were enrolled from April 2004 to June 2007. The median age was 73 yr (range 70–77). Fifteen patients (50%) achieved CR . The 2‐yr DFS was 29% (95% CI , 5–47%), and the 2‐yr OS was 23% (95% CI , 12–35%). Twenty‐five of 69 cycles (36%) were managed on a completely outpatient basis. The median hospital stay per cycle was 10 d (95% CI , 3–25). Conclusions This study demonstrates the tolerability and efficacy of a semi‐intensive treatment in elderly de novo patients with AML managed on an outpatient basis, without substantial toxicity." @default.
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• W2068561263 date "2015-03-16" @default.
• W2068561263 modified "2023-10-18" @default.
• W2068561263 title "Feasibility and efficacy of outpatient therapy with intermediate dose cytarabine, fludarabine and idarubicin for patients with acute myeloid leukaemia aged 70 or older" @default.
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• W2068561263 doi "https://doi.org/10.1111/ejh.12538" @default.
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