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- W2068569512 abstract "Administration of the 2,4-dinitrophenyl (Dnp) determinant conjugated to the “nonimmunogenic” copolymer of D-glutamic acid and D-lysine (D-GL) induces Dnp-specific immunological tolerance which is essentially restricted to bone marrow-derived (B) lymphocytes. Previous studies have demonstrated tolerance induction by Dnp-D-GL in predominantly B lymphocytes of the IgG class. The present studies establish and analyze conditions for tolerance induction in Dnp-specific B lymphocytes of the IgE antibody class by taking advantage of: ( i ) the relatively easy capacity to induce tolerance with Dnp-D-GL in an animal or cell population previously primed to the Dnp determinant; ( ii ) previously established parameters for the successful adoptive transfer of Dnp-specific IgE antibody responses; and ( iii ) the capacity to induce, and maintain a state of Dnp-specific tolerance with Dnp-D-GL in adoptive transfer responses. Using these approaches, we have successfully rendered Dnp-specific B cells of the IgE class profoundly and apparently irreversibly tolerant after exposure of such cells to Dnp-D-GL. These observations represent a starting point of wide potential for solving many therapeutic problems concerned with clinical allergies." @default.
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- W2068569512 date "1973-10-01" @default.
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- W2068569512 title "Induction of Immunological Tolerance in Bone Marrow-Derived Lymphocytes of the IgE Antibody Class" @default.
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- W2068569512 doi "https://doi.org/10.1073/pnas.70.10.2776" @default.
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