FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068572014> ?p ?o ?g. }

• W2068572014 endingPage "9895" @default.
• W2068572014 startingPage "9881" @default.
• W2068572014 abstract "Much evidence shows that acute and chronic inflammation in spinal cord injury (SCI), characterized by immune cell infiltration and release of inflammatory mediators, is implicated in development of the secondary injury phase that occurs after spinal cord trauma and in the worsening of damage. Activation of microglia/macrophages and the associated inflammatory response appears to be a self-propelling mechanism that leads to progressive neurodegeneration and development of persisting pain state. Recent advances in polymer science have provided a huge amount of innovations leading to increased interest for polymeric nanoparticles (NPs) as drug delivery tools to treat SCI. In this study, we tested and evaluated in vitro and in vivo a new drug delivery nanocarrier: minocycline loaded in NPs composed by a polymer based on poly-ε-caprolactone and polyethylene glycol. These NPs are able to selectively target and modulate, specifically, the activated proinflammatory microglia/macrophages in subacute progression of the secondary injury in SCI mouse model. After minocycline-NPs treatment, we demonstrate a reduced activation and proliferation of microglia/macrophages around the lesion site and a reduction of cells with round shape phagocytic-like phenotype in favor of a more arborized resting-like phenotype with low CD68 staining. Treatment here proposed limits, up to 15 days tested, the proinflammatory stimulus associated with microglia/macrophage activation. This was demonstrated by reduced expression of proinflammatory cytokine IL-6 and persistent reduced expression of CD68 in traumatized site. The nanocarrier drug delivery tool developed here shows potential advantages over the conventionally administered anti-inflammatory therapy, maximizing therapeutic efficiency and reducing side effects." @default.
• W2068572014 created "2016-06-24" @default.
• W2068572014 creator A5003417307 @default.
• W2068572014 creator A5004603208 @default.
• W2068572014 creator A5007066407 @default.
• W2068572014 creator A5011192228 @default.
• W2068572014 creator A5015825651 @default.
• W2068572014 creator A5015887544 @default.
• W2068572014 creator A5016120516 @default.
• W2068572014 creator A5034349404 @default.
• W2068572014 creator A5045591592 @default.
• W2068572014 creator A5049100353 @default.
• W2068572014 creator A5049992567 @default.
• W2068572014 creator A5053559594 @default.
• W2068572014 creator A5054951214 @default.
• W2068572014 creator A5057904092 @default.
• W2068572014 creator A5058296666 @default.
• W2068572014 creator A5074581566 @default.
• W2068572014 creator A5075108146 @default.
• W2068572014 creator A5082873368 @default.
• W2068572014 creator A5084544899 @default.
• W2068572014 date "2013-10-18" @default.
• W2068572014 modified "2023-10-18" @default.
• W2068572014 title "Selective Nanovector Mediated Treatment of Activated Proinflammatory Microglia/Macrophages in Spinal Cord Injury" @default.
• W2068572014 cites W1729621315 @default.
• W2068572014 cites W1974960001 @default.
• W2068572014 cites W1978137908 @default.
• W2068572014 cites W1979859079 @default.
• W2068572014 cites W1984737307 @default.
• W2068572014 cites W1985297297 @default.
• W2068572014 cites W1988868629 @default.
• W2068572014 cites W1993544376 @default.
• W2068572014 cites W2002510458 @default.
• W2068572014 cites W2002964521 @default.
• W2068572014 cites W2004704320 @default.
• W2068572014 cites W2006517495 @default.
• W2068572014 cites W2010882645 @default.
• W2068572014 cites W2011916360 @default.
• W2068572014 cites W2013550016 @default.
• W2068572014 cites W2014473140 @default.
• W2068572014 cites W2016721378 @default.
• W2068572014 cites W2023053568 @default.
• W2068572014 cites W2023198955 @default.
• W2068572014 cites W2028742031 @default.
• W2068572014 cites W2035584686 @default.
• W2068572014 cites W2036805729 @default.
• W2068572014 cites W2036878027 @default.
• W2068572014 cites W2044269265 @default.
• W2068572014 cites W2050791093 @default.
• W2068572014 cites W2051300373 @default.
• W2068572014 cites W2052009368 @default.
• W2068572014 cites W2057005337 @default.
• W2068572014 cites W2057711034 @default.
• W2068572014 cites W2062071298 @default.
• W2068572014 cites W2098500386 @default.
• W2068572014 cites W2101685557 @default.
• W2068572014 cites W2109601401 @default.
• W2068572014 cites W2113107925 @default.
• W2068572014 cites W2113617025 @default.
• W2068572014 cites W2115467262 @default.
• W2068572014 cites W2118120380 @default.
• W2068572014 cites W2132259121 @default.
• W2068572014 cites W2133132296 @default.
• W2068572014 cites W2133961780 @default.
• W2068572014 cites W2145636236 @default.
• W2068572014 cites W2147388735 @default.
• W2068572014 cites W2151417786 @default.
• W2068572014 cites W2161456562 @default.
• W2068572014 cites W2323149868 @default.
• W2068572014 doi "https://doi.org/10.1021/nn4036014" @default.
• W2068572014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24138479" @default.
• W2068572014 hasPublicationYear "2013" @default.
• W2068572014 type Work @default.
• W2068572014 sameAs 2068572014 @default.
• W2068572014 citedByCount "126" @default.
• W2068572014 countsByYear W20685720142014 @default.
• W2068572014 countsByYear W20685720142015 @default.
• W2068572014 countsByYear W20685720142016 @default.
• W2068572014 countsByYear W20685720142017 @default.
• W2068572014 countsByYear W20685720142018 @default.
• W2068572014 countsByYear W20685720142019 @default.
• W2068572014 countsByYear W20685720142020 @default.
• W2068572014 countsByYear W20685720142021 @default.
• W2068572014 countsByYear W20685720142022 @default.
• W2068572014 countsByYear W20685720142023 @default.
• W2068572014 crossrefType "journal-article" @default.
• W2068572014 hasAuthorship W2068572014A5003417307 @default.
• W2068572014 hasAuthorship W2068572014A5004603208 @default.
• W2068572014 hasAuthorship W2068572014A5007066407 @default.
• W2068572014 hasAuthorship W2068572014A5011192228 @default.
• W2068572014 hasAuthorship W2068572014A5015825651 @default.
• W2068572014 hasAuthorship W2068572014A5015887544 @default.
• W2068572014 hasAuthorship W2068572014A5016120516 @default.
• W2068572014 hasAuthorship W2068572014A5034349404 @default.
• W2068572014 hasAuthorship W2068572014A5045591592 @default.
• W2068572014 hasAuthorship W2068572014A5049100353 @default.
• W2068572014 hasAuthorship W2068572014A5049992567 @default.
• W2068572014 hasAuthorship W2068572014A5053559594 @default.

• next