FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068573285> ?p ?o ?g. }

• W2068573285 abstract "Bis-diamine is known to induce congenital anomalies including cardiac defects, thymic hypoplasia and snout defects in rat embryos. Cardiovascular lesions consist of persistent truncus arteriosus, tetralogy of Fallot and aortic arch anomalies, which are often found in DiGeorge syndrome. In the the present study, we investigated effects of bisdiamine on cardiac neural crest cells, which may be important to the teratogenecity. A single dose of 200 mg bis-diamine was administered to pregnant rats at 10.5 embryonic day (ED). Immunohistochemical studies were performed on embryos at 11.5, 12.5 and 13.5 ED using anti-HNK-1 and anti-N-CAM antibodies. The embryos at 11.5 and 12.5 ED showed the similar distributional patterns of either HNK-1 or N-CAM positive cells in control and bis-diamine treated embryos. N-CAM immunoreactivities in the splanchnic mesoderm were quite weakly detectable in the bis-diamine treated embryos at 12.5 ED. Closure of the neural tube was delayed in the treated embryos at this period. Immunohistochemistry of the control embryos at 13.5 ED demonstrated a continuous chain of N-CAM expression between the neural plexus near the foregut and the fourth aortic arch, while no apparent continuity of N-CAM positive tissue was observed in the bis-diamine treated embryos. These findings suggested that bis-diamine reduced the amount of neural crest cells which appeared to participate in the aortic arch formation or conotruncal septation. The primary effect of bis-diamine in the induction of various congenital anomalies including cardiovascular malformations may be an inhibition of the normal development of the neural tube and neural crest." @default.
• W2068573285 created "2016-06-24" @default.
• W2068573285 creator A5020240574 @default.
• W2068573285 creator A5032965701 @default.
• W2068573285 creator A5047706524 @default.
• W2068573285 date "1999-12-01" @default.
• W2068573285 modified "2023-09-27" @default.
• W2068573285 title "Immunohistochemical Distribution of HNK-1 and N-CAM in Rat Embryos Treated with Bis-Diamine" @default.
• W2068573285 cites W1970680825 @default.
• W2068573285 cites W1977888295 @default.
• W2068573285 cites W1977978952 @default.
• W2068573285 cites W1981147697 @default.
• W2068573285 cites W1981990420 @default.
• W2068573285 cites W1982499150 @default.
• W2068573285 cites W1983208899 @default.
• W2068573285 cites W1983657098 @default.
• W2068573285 cites W1985268058 @default.
• W2068573285 cites W1990015595 @default.
• W2068573285 cites W1992766436 @default.
• W2068573285 cites W1994155034 @default.
• W2068573285 cites W1999227500 @default.
• W2068573285 cites W2003030958 @default.
• W2068573285 cites W2013250707 @default.
• W2068573285 cites W2015014828 @default.
• W2068573285 cites W2019751650 @default.
• W2068573285 cites W2020559241 @default.
• W2068573285 cites W2031790878 @default.
• W2068573285 cites W2037447292 @default.
• W2068573285 cites W2038209498 @default.
• W2068573285 cites W2044837031 @default.
• W2068573285 cites W2061367928 @default.
• W2068573285 cites W2078393889 @default.
• W2068573285 cites W2103855011 @default.
• W2068573285 cites W2106605663 @default.
• W2068573285 cites W2117926123 @default.
• W2068573285 cites W2128899024 @default.
• W2068573285 cites W2151574237 @default.
• W2068573285 cites W2167986100 @default.
• W2068573285 cites W4240763055 @default.
• W2068573285 doi "https://doi.org/10.1111/j.1741-4520.1999.tb00567.x" @default.
• W2068573285 hasPublicationYear "1999" @default.
• W2068573285 type Work @default.
• W2068573285 sameAs 2068573285 @default.
• W2068573285 citedByCount "4" @default.
• W2068573285 crossrefType "journal-article" @default.
• W2068573285 hasAuthorship W2068573285A5020240574 @default.
• W2068573285 hasAuthorship W2068573285A5032965701 @default.
• W2068573285 hasAuthorship W2068573285A5047706524 @default.
• W2068573285 hasConcept C105702510 @default.
• W2068573285 hasConcept C118552586 @default.
• W2068573285 hasConcept C126322002 @default.
• W2068573285 hasConcept C126749454 @default.
• W2068573285 hasConcept C170774537 @default.
• W2068573285 hasConcept C196843134 @default.
• W2068573285 hasConcept C204232928 @default.
• W2068573285 hasConcept C2778646171 @default.
• W2068573285 hasConcept C2779688345 @default.
• W2068573285 hasConcept C2779980429 @default.
• W2068573285 hasConcept C2780074459 @default.
• W2068573285 hasConcept C2780298129 @default.
• W2068573285 hasConcept C2780594696 @default.
• W2068573285 hasConcept C2781285907 @default.
• W2068573285 hasConcept C71924100 @default.
• W2068573285 hasConcept C86803240 @default.
• W2068573285 hasConcept C87073359 @default.
• W2068573285 hasConcept C95444343 @default.
• W2068573285 hasConceptScore W2068573285C105702510 @default.
• W2068573285 hasConceptScore W2068573285C118552586 @default.
• W2068573285 hasConceptScore W2068573285C126322002 @default.
• W2068573285 hasConceptScore W2068573285C126749454 @default.
• W2068573285 hasConceptScore W2068573285C170774537 @default.
• W2068573285 hasConceptScore W2068573285C196843134 @default.
• W2068573285 hasConceptScore W2068573285C204232928 @default.
• W2068573285 hasConceptScore W2068573285C2778646171 @default.
• W2068573285 hasConceptScore W2068573285C2779688345 @default.
• W2068573285 hasConceptScore W2068573285C2779980429 @default.
• W2068573285 hasConceptScore W2068573285C2780074459 @default.
• W2068573285 hasConceptScore W2068573285C2780298129 @default.
• W2068573285 hasConceptScore W2068573285C2780594696 @default.
• W2068573285 hasConceptScore W2068573285C2781285907 @default.
• W2068573285 hasConceptScore W2068573285C71924100 @default.
• W2068573285 hasConceptScore W2068573285C86803240 @default.
• W2068573285 hasConceptScore W2068573285C87073359 @default.
• W2068573285 hasConceptScore W2068573285C95444343 @default.
• W2068573285 hasLocation W20685732851 @default.
• W2068573285 hasOpenAccess W2068573285 @default.
• W2068573285 hasPrimaryLocation W20685732851 @default.
• W2068573285 hasRelatedWork W1777892343 @default.
• W2068573285 hasRelatedWork W1925816448 @default.
• W2068573285 hasRelatedWork W1971357370 @default.
• W2068573285 hasRelatedWork W1975629679 @default.
• W2068573285 hasRelatedWork W1983002544 @default.
• W2068573285 hasRelatedWork W1986279487 @default.
• W2068573285 hasRelatedWork W2002321922 @default.
• W2068573285 hasRelatedWork W2004294533 @default.
• W2068573285 hasRelatedWork W2010138208 @default.
• W2068573285 hasRelatedWork W2020998468 @default.
• W2068573285 hasRelatedWork W2033656104 @default.
• W2068573285 hasRelatedWork W2062213037 @default.
• W2068573285 hasRelatedWork W2073226772 @default.

• next