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• W2068575246 abstract "Chronic administration of ethanol to rats for 6–8 weeks caused an elevation in the concentration of cytochrome P-450 and an enhancement of the rates of drug oxidation and UDP-glucuronic acid conjugation in isolated hepatocytes. The oxidation of harmine was stimulated by 100 per cent with a concomitant increase in the glucuronide formation. When paracetamol and harmol were used as specific substrates of conjugation reactions, the rate of glucuronide formation was increased by about 50 per cent, while the rate of sulphate conjugation was not affected. The cytochrome P-450 dependent activation of paracetamol, measured as glutathione conjugate formation, increased about three-fold. The intracellular GSH concentration, which was not affected by ethanol treatment, decreased stoichiometrically with the formation of paracetamol-glutathione conjugate. Furthermore, the binding affinity of paracetamol to cytochrome P-450 was increased after ethanol administration. In isolated kidney cells the formation of sulfhydryl conjugates of paracetamol was increased after chronic ethanol administration." @default.
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• W2068575246 date "1980-06-01" @default.
• W2068575246 modified "2023-10-10" @default.
• W2068575246 title "Effect of chronic ethanol administration on drug metabolism in isolated hepatocytes with emphasis on paracetamol activation" @default.
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• W2068575246 doi "https://doi.org/10.1016/0006-2952(80)90134-3" @default.
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