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- W2068579042 abstract "Fetotoxicity of di-(2-ethylhexyl)phthalate (DEHP) was studied in a random strain (ddY-Slc♀ × CBA ♂) of mice. A single oral administration of DEHP 0.05 ml/kg on day 7 of gestation resulted in a decrease in body weight of live fetuses, but there were no dead, gross, or skeletal abnormal fetuses. At 0.1 ml/kg and above DEHP decreased fetal body weight and the fetuses were dead or deformed. The fetotoxicity was dose dependent and a straight line Y = 51.9 log X + 61.6 was obtained where Y = the rate of death(%) and X = the dose of DEHP administered (ml/kg). The LD50 and the non-effective aximum dose which induced fetal death was 0.60 ml/kg and 0.065 ml/kg, respectively. The non-effective maximum doses which resulted in gross and skeletal abnormalities were 0.80 and 0.68 ml/kg, respectively." @default.
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- W2068579042 date "1979-08-01" @default.
- W2068579042 modified "2023-10-15" @default.
- W2068579042 title "Teratogenicity of di-(2-ethylhexyl)phthalate in mice" @default.
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- W2068579042 doi "https://doi.org/10.1016/0378-4274(79)90084-5" @default.
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