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- W2068579230 abstract "Deuterated arachidonic acid (AA, [2H820 :4 n-6) 1–25 μM, is converted to other fatty acids, as evaluated by gas chromatography-mass spectrometry, in THP-1 cells. The major products, in the 1 to 10 μM range, are 22:4 (elongated) and 20:3 (reduced in 5). At 25 μM, 24:4, 24:5 and 22:5 accumulate, with [2H8]/[2H0] ratios higher than in AA. At high AA concentration preferential conversion to elongated fatty acids with 5 unsaturations, through a 6 desaturase takes place and the 4-desaturated 22:5 appears to be formed through β-oxidation of 24:5." @default.
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- W2068579230 date "1994-05-02" @default.
- W2068579230 modified "2023-10-17" @default.
- W2068579230 title "Formation of 22 and 24 carbon 6-desaturated fatty acids from exogenous deuterated arachidonic acid is activated in THP-1 cells at high substrate concentrations" @default.
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- W2068579230 doi "https://doi.org/10.1016/0014-5793(94)80554-7" @default.
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