FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068579914> ?p ?o ?g. }

• W2068579914 endingPage "111" @default.
• W2068579914 startingPage "107" @default.
• W2068579914 abstract "Using a synthetic peptide strategy, we localized an active domain in mouse leptin to a sequence between amino acids 106 and 140. Intraperitoneal (ip) administration of a number of synthetic peptide amides encompassed by this domain reduced body weight gain, food and water intake, blood glucose levels, and increased insulin sensitivity in genetically obese mice. In the present study, we examined the pharmacokinetics of mouse [D-Leu-4]OB3, our most potent peptide, in male Swiss Webster mice following ip, subcutaneous (sc), and intramuscular (im) injection, and after intranasal administration with Intravail, a new class of patented transmucosal delivery enhancement agents. Total uptake (1,072,270, 1,182,498; 1,481,060; ng/ml/min), serum half-life (48.8; 34.0; 30.0 min) and relative bioavailability (1.0, 1.1; 1.4;) of mouse [D-Leu-4]OB3 were similar when the peptide was given by ip, sc, or im injection, respectively. Total uptake and relative bioavailability were enhanced following intranasal delivery (4,336,963 ng/ml/min and 4.0, respectively), and serum half-life was 41.1 min. These results indicate that intranasal delivery of mouse [D-Leu-4]OB3 with Intravail is a more effective method of peptide administration than injection methods, and suggest that it may have potential as a novel, non-invasive approach to the treatment of obesity and its associated metabolic dysfunctions in humans." @default.
• W2068579914 created "2016-06-24" @default.
• W2068579914 creator A5023843257 @default.
• W2068579914 creator A5024254526 @default.
• W2068579914 creator A5043497382 @default.
• W2068579914 creator A5076065961 @default.
• W2068579914 date "2009-04-01" @default.
• W2068579914 modified "2023-10-17" @default.
• W2068579914 title "Intranasal administration of mouse [D-Leu-4]OB3, a synthetic peptide amide with leptin-like activity, enhances total uptake and bioavailability in Swiss Webster mice when compared to intraperitoneal, subcutaneous, and intramuscular delivery systems" @default.
• W2068579914 cites W1631449371 @default.
• W2068579914 cites W1927710737 @default.
• W2068579914 cites W1965966174 @default.
• W2068579914 cites W1984735014 @default.
• W2068579914 cites W1993008014 @default.
• W2068579914 cites W1996713062 @default.
• W2068579914 cites W2010189959 @default.
• W2068579914 cites W2011058575 @default.
• W2068579914 cites W2013583119 @default.
• W2068579914 cites W2014093920 @default.
• W2068579914 cites W2036958830 @default.
• W2068579914 cites W2060682066 @default.
• W2068579914 cites W2065738278 @default.
• W2068579914 cites W2066433992 @default.
• W2068579914 cites W2073447073 @default.
• W2068579914 cites W2076319379 @default.
• W2068579914 cites W2081553125 @default.
• W2068579914 cites W2098305958 @default.
• W2068579914 cites W2101746873 @default.
• W2068579914 cites W2105987351 @default.
• W2068579914 cites W2116843182 @default.
• W2068579914 cites W2117685065 @default.
• W2068579914 cites W2120207654 @default.
• W2068579914 cites W2123533552 @default.
• W2068579914 cites W2158288461 @default.
• W2068579914 cites W2162565031 @default.
• W2068579914 cites W2172088278 @default.
• W2068579914 cites W2319361543 @default.
• W2068579914 doi "https://doi.org/10.1016/j.regpep.2009.01.002" @default.
• W2068579914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19344673" @default.
• W2068579914 hasPublicationYear "2009" @default.
• W2068579914 type Work @default.
• W2068579914 sameAs 2068579914 @default.
• W2068579914 citedByCount "27" @default.
• W2068579914 countsByYear W20685799142012 @default.
• W2068579914 countsByYear W20685799142013 @default.
• W2068579914 countsByYear W20685799142014 @default.
• W2068579914 countsByYear W20685799142015 @default.
• W2068579914 countsByYear W20685799142017 @default.
• W2068579914 countsByYear W20685799142018 @default.
• W2068579914 countsByYear W20685799142020 @default.
• W2068579914 countsByYear W20685799142021 @default.
• W2068579914 countsByYear W20685799142022 @default.
• W2068579914 countsByYear W20685799142023 @default.
• W2068579914 crossrefType "journal-article" @default.
• W2068579914 hasAuthorship W2068579914A5023843257 @default.
• W2068579914 hasAuthorship W2068579914A5024254526 @default.
• W2068579914 hasAuthorship W2068579914A5043497382 @default.
• W2068579914 hasAuthorship W2068579914A5076065961 @default.
• W2068579914 hasConcept C112705442 @default.
• W2068579914 hasConcept C126322002 @default.
• W2068579914 hasConcept C134018914 @default.
• W2068579914 hasConcept C181389837 @default.
• W2068579914 hasConcept C185592680 @default.
• W2068579914 hasConcept C2776093070 @default.
• W2068579914 hasConcept C2776291583 @default.
• W2068579914 hasConcept C2776390293 @default.
• W2068579914 hasConcept C2779281246 @default.
• W2068579914 hasConcept C2780159080 @default.
• W2068579914 hasConcept C2780613262 @default.
• W2068579914 hasConcept C511355011 @default.
• W2068579914 hasConcept C55493867 @default.
• W2068579914 hasConcept C71924100 @default.
• W2068579914 hasConcept C85663871 @default.
• W2068579914 hasConcept C98274493 @default.
• W2068579914 hasConceptScore W2068579914C112705442 @default.
• W2068579914 hasConceptScore W2068579914C126322002 @default.
• W2068579914 hasConceptScore W2068579914C134018914 @default.
• W2068579914 hasConceptScore W2068579914C181389837 @default.
• W2068579914 hasConceptScore W2068579914C185592680 @default.
• W2068579914 hasConceptScore W2068579914C2776093070 @default.
• W2068579914 hasConceptScore W2068579914C2776291583 @default.
• W2068579914 hasConceptScore W2068579914C2776390293 @default.
• W2068579914 hasConceptScore W2068579914C2779281246 @default.
• W2068579914 hasConceptScore W2068579914C2780159080 @default.
• W2068579914 hasConceptScore W2068579914C2780613262 @default.
• W2068579914 hasConceptScore W2068579914C511355011 @default.
• W2068579914 hasConceptScore W2068579914C55493867 @default.
• W2068579914 hasConceptScore W2068579914C71924100 @default.
• W2068579914 hasConceptScore W2068579914C85663871 @default.
• W2068579914 hasConceptScore W2068579914C98274493 @default.
• W2068579914 hasIssue "1-3" @default.
• W2068579914 hasLocation W20685799141 @default.
• W2068579914 hasLocation W20685799142 @default.
• W2068579914 hasOpenAccess W2068579914 @default.
• W2068579914 hasPrimaryLocation W20685799141 @default.
• W2068579914 hasRelatedWork W1929084877 @default.
• W2068579914 hasRelatedWork W2015263964 @default.
• W2068579914 hasRelatedWork W2036364847 @default.

• next