Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068583266> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2068583266 endingPage "233" @default.
- W2068583266 startingPage "225" @default.
- W2068583266 abstract "In order to confirm the multiple neurotransmitter biosynthetic ability, the possibility of separation of the activities of tyrosine hydroxylase (TH), choline acetyltransferase and glutamic acid decar☐ylase was tested by subcloning of a clonal rat pheochromocytoma PC12 cell line. All of 9 subclones obtained showed significant activities of above 3 enzymes, indicating that the PC12 cell has multi-functional properties of neurotransmitter syntheses. One of the subclones, designated PC12h, was demonstrated to have nerve growth factor- (NGF) responsive TH activity. The ED50 value of NGF to increase the TH activity was 1.7 ng/ml (6.5 × 10−11M). A simultaneous addition of saturating amounts of NGF (50 ng/ml) and dexamethasone (10−6 M) resulted in the increase of TH activity that is equal to the sum of those achieved when either effector was added separately, indicating that the NGF-mediated increase of TH activity in PC12h cells was independent upon the effect of dexamethasone. And also, the TH activity increased by NGF was somewhat potentiated in PC12h cells cultured in a hormone-supplemented serum-free medium." @default.
- W2068583266 created "2016-06-24" @default.
- W2068583266 creator A5005841735 @default.
- W2068583266 date "1981-10-01" @default.
- W2068583266 modified "2023-09-25" @default.
- W2068583266 title "Nerve growth factor-mediated stimulation of tyrosine hydroxylase activity in a clonal rat pheochromocytoma cell line" @default.
- W2068583266 cites W1775749144 @default.
- W2068583266 cites W1972525015 @default.
- W2068583266 cites W1973687723 @default.
- W2068583266 cites W1985082993 @default.
- W2068583266 cites W1989425013 @default.
- W2068583266 cites W1992623778 @default.
- W2068583266 cites W2002516449 @default.
- W2068583266 cites W2008660829 @default.
- W2068583266 cites W2011543201 @default.
- W2068583266 cites W2014731769 @default.
- W2068583266 cites W2026127911 @default.
- W2068583266 cites W2028598564 @default.
- W2068583266 cites W2044299655 @default.
- W2068583266 cites W2084503441 @default.
- W2068583266 cites W2090900962 @default.
- W2068583266 cites W2095873344 @default.
- W2068583266 cites W2121790796 @default.
- W2068583266 cites W2174825349 @default.
- W2068583266 doi "https://doi.org/10.1016/0006-8993(81)91029-5" @default.
- W2068583266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6116517" @default.
- W2068583266 hasPublicationYear "1981" @default.
- W2068583266 type Work @default.
- W2068583266 sameAs 2068583266 @default.
- W2068583266 citedByCount "192" @default.
- W2068583266 countsByYear W20685832662012 @default.
- W2068583266 countsByYear W20685832662013 @default.
- W2068583266 countsByYear W20685832662014 @default.
- W2068583266 countsByYear W20685832662015 @default.
- W2068583266 countsByYear W20685832662016 @default.
- W2068583266 countsByYear W20685832662018 @default.
- W2068583266 countsByYear W20685832662019 @default.
- W2068583266 countsByYear W20685832662022 @default.
- W2068583266 crossrefType "journal-article" @default.
- W2068583266 hasAuthorship W2068583266A5005841735 @default.
- W2068583266 hasConcept C126322002 @default.
- W2068583266 hasConcept C134018914 @default.
- W2068583266 hasConcept C159167319 @default.
- W2068583266 hasConcept C170493617 @default.
- W2068583266 hasConcept C185592680 @default.
- W2068583266 hasConcept C198399640 @default.
- W2068583266 hasConcept C22885893 @default.
- W2068583266 hasConcept C24998067 @default.
- W2068583266 hasConcept C2776219046 @default.
- W2068583266 hasConcept C2778423431 @default.
- W2068583266 hasConcept C42533223 @default.
- W2068583266 hasConcept C513476851 @default.
- W2068583266 hasConcept C529278444 @default.
- W2068583266 hasConcept C54355233 @default.
- W2068583266 hasConcept C71924100 @default.
- W2068583266 hasConcept C81885089 @default.
- W2068583266 hasConcept C86803240 @default.
- W2068583266 hasConceptScore W2068583266C126322002 @default.
- W2068583266 hasConceptScore W2068583266C134018914 @default.
- W2068583266 hasConceptScore W2068583266C159167319 @default.
- W2068583266 hasConceptScore W2068583266C170493617 @default.
- W2068583266 hasConceptScore W2068583266C185592680 @default.
- W2068583266 hasConceptScore W2068583266C198399640 @default.
- W2068583266 hasConceptScore W2068583266C22885893 @default.
- W2068583266 hasConceptScore W2068583266C24998067 @default.
- W2068583266 hasConceptScore W2068583266C2776219046 @default.
- W2068583266 hasConceptScore W2068583266C2778423431 @default.
- W2068583266 hasConceptScore W2068583266C42533223 @default.
- W2068583266 hasConceptScore W2068583266C513476851 @default.
- W2068583266 hasConceptScore W2068583266C529278444 @default.
- W2068583266 hasConceptScore W2068583266C54355233 @default.
- W2068583266 hasConceptScore W2068583266C71924100 @default.
- W2068583266 hasConceptScore W2068583266C81885089 @default.
- W2068583266 hasConceptScore W2068583266C86803240 @default.
- W2068583266 hasIssue "2" @default.
- W2068583266 hasLocation W20685832661 @default.
- W2068583266 hasLocation W20685832662 @default.
- W2068583266 hasOpenAccess W2068583266 @default.
- W2068583266 hasPrimaryLocation W20685832661 @default.
- W2068583266 hasRelatedWork W1979059193 @default.
- W2068583266 hasRelatedWork W1984619393 @default.
- W2068583266 hasRelatedWork W2026017212 @default.
- W2068583266 hasRelatedWork W2034768996 @default.
- W2068583266 hasRelatedWork W2054992011 @default.
- W2068583266 hasRelatedWork W2062579683 @default.
- W2068583266 hasRelatedWork W2064416809 @default.
- W2068583266 hasRelatedWork W2068583266 @default.
- W2068583266 hasRelatedWork W2163744984 @default.
- W2068583266 hasRelatedWork W2157445022 @default.
- W2068583266 hasVolume "222" @default.
- W2068583266 isParatext "false" @default.
- W2068583266 isRetracted "false" @default.
- W2068583266 magId "2068583266" @default.
- W2068583266 workType "article" @default.