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• W2068586154 abstract "<i>Aim:</i> The purpose of this study was to develop an accurate regression model to predict insulin resistance in girls with premature adrenarche. <i>Methods:</i> The insulin sensitivity index was calculated from the frequently sampled intravenous glucose tolerance test with tolbutamide. Thirty-five prepubertal girls (23 Caribbean-Hispanic and 12 African-American; mean age 6.8 years) were studied. The insulin sensitivity index was compared to birth weight, body mass index (BMI), the presence of acanthosis nigricans (AN), insulin-like growth factor 1, insulin-like growth factor binding protein 1, sex hormone binding globulin, lipid profile, and adrenocorticotropic hormone stimulated androgens. <i>Results:</i> The best prediction models included birth weight, BMI, and AN (model 1: R² = 0.78) and BMI, AN, and serum 17-OH pregnenolone (model 2: R² = 0.76). When viewed as screening tests, a cutoff value <5.5 (premature adrenarche insulin resistance score) in both equations showed a sensitivity of 100% and a specificity of 85%. <i>Conclusion:</i> Born small for gestational age, premature adrenarche, obesity, AN, and higher serum 17-OH pregnenolone levels may confer negative, but independent, health risks." @default.
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• W2068586154 date "2006-01-01" @default.
• W2068586154 modified "2023-09-27" @default.
• W2068586154 title "Prediction Models for Insulin Resistance in Girls with Premature Adrenarche" @default.
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• W2068586154 doi "https://doi.org/10.1159/000092103" @default.
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