Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068588466> ?p ?o ?g. }
- W2068588466 endingPage "203" @default.
- W2068588466 startingPage "187" @default.
- W2068588466 abstract "Antibodies with modest neutralizing activity and narrow breadth are commonly elicited in HIV-1. Here, we evaluated the complementary and synergistic activities of a set of monoclonal antibodies (MAb) isolated from a single patient, directed to V3, CD4 binding site (CD4bs), and CD4 induced (CD4i) epitopes. Despite low somatic hypermutation percentages in the variable regions, these MAbs covered viral strains from subtypes B, C, A and CRF01_AE and transmitted/founder viruses in terms of binding, neutralizing and antibody-dependent cell-mediated cytotoxicity (ADCC) activities. In addition, a combination of the anti-V3 and CD4bs MAbs showed a synergistic effect over the neutralization of HIV-1JR-FL. A humoral response from a single patient covered a wide range of viruses by complementary and synergistic activities of antibodies with different specificities. Inducing a set of narrow neutralizing antibodies, easier to induce than the broadly neutralizing antibodies, could be a strategy for developing an effective vaccine against HIV-1." @default.
- W2068588466 created "2016-06-24" @default.
- W2068588466 creator A5014453137 @default.
- W2068588466 creator A5032006477 @default.
- W2068588466 creator A5043565390 @default.
- W2068588466 creator A5044801294 @default.
- W2068588466 creator A5061229015 @default.
- W2068588466 creator A5075747785 @default.
- W2068588466 creator A5084779588 @default.
- W2068588466 date "2015-01-01" @default.
- W2068588466 modified "2023-09-29" @default.
- W2068588466 title "Complementary and synergistic activities of anti-V3, CD4bs and CD4i antibodies derived from a single individual can cover a wide range of HIV-1 strains" @default.
- W2068588466 cites W1513182170 @default.
- W2068588466 cites W1528520360 @default.
- W2068588466 cites W1966092083 @default.
- W2068588466 cites W1969156908 @default.
- W2068588466 cites W1969234460 @default.
- W2068588466 cites W1971233211 @default.
- W2068588466 cites W1974310392 @default.
- W2068588466 cites W1976344112 @default.
- W2068588466 cites W1976595872 @default.
- W2068588466 cites W1979886683 @default.
- W2068588466 cites W1982084239 @default.
- W2068588466 cites W1983262897 @default.
- W2068588466 cites W1990745725 @default.
- W2068588466 cites W1992566288 @default.
- W2068588466 cites W1993355882 @default.
- W2068588466 cites W1994322627 @default.
- W2068588466 cites W1994492306 @default.
- W2068588466 cites W1995466180 @default.
- W2068588466 cites W1996011751 @default.
- W2068588466 cites W1996720451 @default.
- W2068588466 cites W2000984427 @default.
- W2068588466 cites W2002574877 @default.
- W2068588466 cites W2002944156 @default.
- W2068588466 cites W2003380951 @default.
- W2068588466 cites W2005141763 @default.
- W2068588466 cites W2005228785 @default.
- W2068588466 cites W2007607803 @default.
- W2068588466 cites W2009151161 @default.
- W2068588466 cites W2013003141 @default.
- W2068588466 cites W2013914180 @default.
- W2068588466 cites W2015096538 @default.
- W2068588466 cites W2018288116 @default.
- W2068588466 cites W2022221356 @default.
- W2068588466 cites W2024287923 @default.
- W2068588466 cites W2027714523 @default.
- W2068588466 cites W2029804942 @default.
- W2068588466 cites W2030129290 @default.
- W2068588466 cites W2044296969 @default.
- W2068588466 cites W2047659977 @default.
- W2068588466 cites W2051364248 @default.
- W2068588466 cites W2052149946 @default.
- W2068588466 cites W2054351966 @default.
- W2068588466 cites W2057961805 @default.
- W2068588466 cites W2059239545 @default.
- W2068588466 cites W2061282849 @default.
- W2068588466 cites W2062204035 @default.
- W2068588466 cites W2065329551 @default.
- W2068588466 cites W2068343964 @default.
- W2068588466 cites W2070258047 @default.
- W2068588466 cites W2070591048 @default.
- W2068588466 cites W2078557462 @default.
- W2068588466 cites W2081291921 @default.
- W2068588466 cites W2081313987 @default.
- W2068588466 cites W2083726777 @default.
- W2068588466 cites W2083803997 @default.
- W2068588466 cites W2084310667 @default.
- W2068588466 cites W2084341498 @default.
- W2068588466 cites W2085577978 @default.
- W2068588466 cites W2085914785 @default.
- W2068588466 cites W2085988761 @default.
- W2068588466 cites W2087413306 @default.
- W2068588466 cites W2095706923 @default.
- W2068588466 cites W2096587304 @default.
- W2068588466 cites W2097038786 @default.
- W2068588466 cites W2098781795 @default.
- W2068588466 cites W2099308199 @default.
- W2068588466 cites W2099904971 @default.
- W2068588466 cites W2100265029 @default.
- W2068588466 cites W2102254707 @default.
- W2068588466 cites W2103912859 @default.
- W2068588466 cites W2105903892 @default.
- W2068588466 cites W2109912655 @default.
- W2068588466 cites W2110287237 @default.
- W2068588466 cites W2110499527 @default.
- W2068588466 cites W2113236498 @default.
- W2068588466 cites W2113822425 @default.
- W2068588466 cites W2114288367 @default.
- W2068588466 cites W2116358235 @default.
- W2068588466 cites W2116983636 @default.
- W2068588466 cites W2117211286 @default.
- W2068588466 cites W2118274231 @default.
- W2068588466 cites W2121096721 @default.
- W2068588466 cites W2125231927 @default.
- W2068588466 cites W2126255146 @default.
- W2068588466 cites W2127249709 @default.
- W2068588466 cites W2128461524 @default.