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• W2068588703 abstract "Leishmania braziliensis panamensis promastigotes were incubated with glucose as the sole carbon source. About one-fifth of the glucose consumed under aerobic conditions was oxidized to CO2. Nuclear magnetic resonance studies with [1-13C]glucose showed that the other products released were succinate, acetate, alanine, pyruvate, and lactate. Under anaerobic conditions, lactate output increased, glycerol became a major product, and, surprisingly, glucose consumption decreased. Enzymatic assays showed that the lactate formed was D(-)-lactate. The release of alanine during incubation with glucose as the sole carbon source suggested that appreciable proteolysis occurred, consistent with our observation that a large amount of ammonia was released under these conditions. The discoveries that D-lactate is a product of L. braziliensis glucose catabolism, that glycerol is produced under anaerobic conditions, and that the cells exhibit a reverse Pasteur effect open the way for detailed studies of the pathways of glucose metabolism and their regulation in this organism." @default.
• W2068588703 created "2016-06-24" @default.
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• W2068588703 date "1987-10-01" @default.
• W2068588703 modified "2023-09-29" @default.
• W2068588703 title "Products of Leishmania braziliensis glucose catabolism: release of D-lactate and, under anaerobic conditions, glycerol." @default.
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• W2068588703 doi "https://doi.org/10.1073/pnas.84.20.7129" @default.
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