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- W2068589430 abstract "Optimal T-cell activation requires both an antigen-specific and a costimulatory signal. CD167 is a tyrosine kinase receptor for native type I collagen, its physiologic functions include matrix homeostasis and cell growth, adhesion, branching, and migration, but the specific role of CD167 in T cells has not yet been characterized. In this study, we found that CD167 expression on T cells was up-regulated after activation. Cooperation of CD167 engagement with suboptimal TCR/CD3 signals induced T-cell proliferation, enhanced expression of activation markers such as CD25 and CD69, elevated intracellular calcium mobilization and tyrosine phosphorylation, and introduced a bias toward a TH1/Tc1 immune response. Cooperation of CD167 engagement also enhanced mixed lymphocyte responses to alloantigens. Moreover, CD167 rapidly localized to the aggregated lipid rafts upon T-cell activation, this provided a molecular base for the signaling machinery of CD167. Together these findings, we demonstrate for the first time that CD167 could serve as a novel costimulatory receptor for T-cell activation." @default.
- W2068589430 created "2016-06-24" @default.
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- W2068589430 date "2009-10-01" @default.
- W2068589430 modified "2023-09-22" @default.
- W2068589430 title "CD167 Acts as a Novel Costimulatory Receptor in T-Cell Activation" @default.
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- W2068589430 doi "https://doi.org/10.1097/cji.0b013e3181acea46" @default.
- W2068589430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19752756" @default.
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