FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068590105> ?p ?o ?g. }

• W2068590105 endingPage "705" @default.
• W2068590105 startingPage "693" @default.
• W2068590105 abstract "Heat shock proteins (HSPs) are chaperones that are known to have important roles in facilitating protein synthesis, protein assembly and cellular protection. While HSPs are known to be induced by damaging exercise, little is known about how HSPs actually mediate skeletal muscle adaption to exercise. The purpose of this study was to determine the effects of a heat shock pretreatment and the ensuing increase in HSP expression on early remodeling and signaling (2 and 48 h) events of the soleus (Sol) muscle following a bout of downhill running. Male Wistar rats (10 weeks old) were randomly assigned to control, eccentric exercise (EE; downhill running) or heat shock + eccentric exercise (HS; 41°C for 20 min, 48 h prior to exercise) groups. Markers of muscle damage, muscle regeneration and intracellular signaling were assessed. The phosphorylation (p) of HSP25, Akt, p70s6k, ERK1/2 and JNK proteins was also performed. As expected, following exercise the EE group had increased creatine kinase (CK; 2 h) and mononuclear cell infiltration (48 h) compared to controls. The EE group had an increase in p-HSP25, but there was no change in HSP72 expression, total protein concentration, or neonatal MHC content. Additionally, the EE group had increased p-p70s6k, p-ERK1/2, and p-JNK (2 h) compared to controls; however no changes in p-Akt were seen. In contrast, the HS group had reduced CK (2 h) and mononuclear cell infiltration (48 h) compared to EE. Moreover, the HS group had increased HSP72 content (2 and 48 h), total protein concentration (48 h), neonatal MHC content (2 and 48 h), p-HSP25 and p-p70s6k (2 h). Lastly, the HS group had reduced p-Akt (48 h) and p-ERK1/2 (2 h). These data suggest that heat shock pretreatment and/or the ensuing HSP72 response may protect against muscle damage, and enhance increases in total protein and neonatal MHC content following exercise. These changes appear to be independent of Akt and MAPK signaling pathways." @default.
• W2068590105 created "2016-06-24" @default.
• W2068590105 creator A5014849859 @default.
• W2068590105 creator A5016134656 @default.
• W2068590105 creator A5019233665 @default.
• W2068590105 creator A5026218835 @default.
• W2068590105 creator A5053184975 @default.
• W2068590105 creator A5075051906 @default.
• W2068590105 date "2012-05-17" @default.
• W2068590105 modified "2023-10-16" @default.
• W2068590105 title "Acute heat stress prior to downhill running may enhance skeletal muscle remodeling" @default.
• W2068590105 cites W1523923451 @default.
• W2068590105 cites W1579542095 @default.
• W2068590105 cites W1586159393 @default.
• W2068590105 cites W1901873593 @default.
• W2068590105 cites W1910747976 @default.
• W2068590105 cites W1966543081 @default.
• W2068590105 cites W1968663121 @default.
• W2068590105 cites W1978011903 @default.
• W2068590105 cites W1981878314 @default.
• W2068590105 cites W1982618760 @default.
• W2068590105 cites W1983143790 @default.
• W2068590105 cites W1983230033 @default.
• W2068590105 cites W1985994693 @default.
• W2068590105 cites W1986090679 @default.
• W2068590105 cites W1991823700 @default.
• W2068590105 cites W1997327235 @default.
• W2068590105 cites W1997797812 @default.
• W2068590105 cites W1998479989 @default.
• W2068590105 cites W2003025962 @default.
• W2068590105 cites W2003039907 @default.
• W2068590105 cites W2003115478 @default.
• W2068590105 cites W2003404359 @default.
• W2068590105 cites W2005833386 @default.
• W2068590105 cites W2007587875 @default.
• W2068590105 cites W2013349207 @default.
• W2068590105 cites W2014719728 @default.
• W2068590105 cites W2015422840 @default.
• W2068590105 cites W2015744837 @default.
• W2068590105 cites W2016042291 @default.
• W2068590105 cites W2017037484 @default.
• W2068590105 cites W2017353764 @default.
• W2068590105 cites W2021745069 @default.
• W2068590105 cites W2033079374 @default.
• W2068590105 cites W2037045758 @default.
• W2068590105 cites W2040160413 @default.
• W2068590105 cites W2042013057 @default.
• W2068590105 cites W2042541813 @default.
• W2068590105 cites W2044328618 @default.
• W2068590105 cites W2046567657 @default.
• W2068590105 cites W2050839675 @default.
• W2068590105 cites W2051300216 @default.
• W2068590105 cites W2052789372 @default.
• W2068590105 cites W2057330595 @default.
• W2068590105 cites W2058811641 @default.
• W2068590105 cites W2059024838 @default.
• W2068590105 cites W2067708969 @default.
• W2068590105 cites W2073485247 @default.
• W2068590105 cites W2074579328 @default.
• W2068590105 cites W2076811165 @default.
• W2068590105 cites W2078300690 @default.
• W2068590105 cites W2089739115 @default.
• W2068590105 cites W2094240964 @default.
• W2068590105 cites W2095703388 @default.
• W2068590105 cites W2096587517 @default.
• W2068590105 cites W2098746532 @default.
• W2068590105 cites W2101768255 @default.
• W2068590105 cites W2103103443 @default.
• W2068590105 cites W2103795143 @default.
• W2068590105 cites W2105606007 @default.
• W2068590105 cites W2107033751 @default.
• W2068590105 cites W2110559333 @default.
• W2068590105 cites W2114274737 @default.
• W2068590105 cites W2116991275 @default.
• W2068590105 cites W2118217855 @default.
• W2068590105 cites W2128823677 @default.
• W2068590105 cites W2129525035 @default.
• W2068590105 cites W2131333364 @default.
• W2068590105 cites W2131824087 @default.
• W2068590105 cites W2137051079 @default.
• W2068590105 cites W2137952321 @default.
• W2068590105 cites W2138476456 @default.
• W2068590105 cites W2141399230 @default.
• W2068590105 cites W2142158928 @default.
• W2068590105 cites W2148331882 @default.
• W2068590105 cites W2149135437 @default.
• W2068590105 cites W2153939403 @default.
• W2068590105 cites W2157386619 @default.
• W2068590105 cites W2158539746 @default.
• W2068590105 cites W2159680569 @default.
• W2068590105 cites W2162483267 @default.
• W2068590105 cites W2163819745 @default.
• W2068590105 cites W2165199606 @default.
• W2068590105 cites W2166380676 @default.
• W2068590105 cites W2166546066 @default.
• W2068590105 cites W2167959462 @default.
• W2068590105 cites W2209299714 @default.
• W2068590105 cites W2262118508 @default.

• next