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- W2068591738 abstract "Electron probe X‐ray microanalysis revealed that cytoplasmic Ca 2+ concentration increased in the restricted apical cytoplasm during stimulation of isolated guinea pig parietal cells with gastrin. Furthermore, this study, using 45 Ca 2+ , aequorin and fura‐2, revealed the mechanism involved in intracellular Ca 2+ shifts caused by gastrin and the involvements of inositol 1,4,5‐trisphosphate (IP 3 ) and diacylglycerol in producing those shifts. The gastrin‐mediated and IP 3 ‐sensitive Ca 2+ pool was located in the smooth‐surfaced membrane‐enriched areas and released Ca 2+ in the initial phase. Gastrin‐mediated Ca 2+ mobilization was also evoked by diacylglycerol, comprising an intracellular Ca 2+ mobilization followed by a late, sustained and more localised Ca 2+ entry from the extracellular space." @default.
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- W2068591738 date "1988-05-09" @default.
- W2068591738 modified "2023-10-14" @default.
- W2068591738 title "Initial and sustained calcium mobilizations in the parietal cell during stimulations with gastrin, inositol trisphosphate, phorbol ester and erogenous diacylglycerol" @default.
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- W2068591738 doi "https://doi.org/10.1016/0014-5793(88)80391-0" @default.
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