FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068592783> ?p ?o ?g. }

• W2068592783 endingPage "2133" @default.
• W2068592783 startingPage "2125" @default.
• W2068592783 abstract "Purpose Clinical, experimental, and neuroimaging data all indicate that the thalamus is involved in the network of changes associated with temporal lobe epilepsy (TLE), particularly in association with hippocampal sclerosis (HS), with potential roles in seizure initiation and propagation. Pathologic changes in the thalamus may be a result of an initial insult, ongoing seizures, or retrograde degeneration through reciprocal connections between thalamic and limbic regions. Our aim was to carry out a neuropathologic analysis of the thalamus in a postmortem (PM) epilepsy series, to assess the distribution, severity, and nature of pathologic changes and its association with HS. Methods Twenty-four epilepsy PM cases (age range 25–87 years) and eight controls (age range 38–85 years) were studied. HS was classified as unilateral (UHS, 11 cases), bilateral (BHS, 4 cases) or absent (No-HS, 9 cases). Samples from the left and right sides of the thalamus were stained with cresyl violet (CV), and for glial firbillary acidic protein (GFAP) and synaptophysin. Using image analysis, neuronal densities (NDs) or field fraction staining values (GFAP, synaptophysin) were measured in four thalamic nuclei: anteroventral nucleus (AV), lateral dorsal nucleus (LD), mediodorsal nucleus (MD), and ventrolateral nucleus (VL). The results were compared within and between cases. Key Findings The severity, nature, and distribution of thalamic pathology varied between cases. A pattern that emerged was a preferential involvement of the MD in UHS cases with a reduction in mean ND ipsilateral to the side of HS (p = 0.05). In UHS cases, greater field fraction values for GFAP and lower values for synaptophysin and ND were seen in the majority of cases in the MD ipsilateral to the side of sclerosis compared to other thalamic nuclei. In addition, differences in the mean ND between classical HS, atypical HS, and No-HS cases were noted in the ipsilateral MD (p < 0.05), with lower values observed in HS. Significance Our study demonstrates that stereotypical pathologic changes, as seen in HS, are not clearly defined in the thalamus. This may be partly explained by the heterogeneity of our PM study group. With quantitation, there is some evidence for preferential involvement of the MD, suggesting a potential role in TLE, which requires further investigation." @default.
• W2068592783 created "2016-06-24" @default.
• W2068592783 creator A5049258088 @default.
• W2068592783 creator A5060298546 @default.
• W2068592783 creator A5074816207 @default.
• W2068592783 creator A5078902556 @default.
• W2068592783 date "2013-10-18" @default.
• W2068592783 modified "2023-09-25" @default.
• W2068592783 title "Regional thalamic neuropathology in patients with hippocampal sclerosis and epilepsy: A postmortem study" @default.
• W2068592783 cites W1492331633 @default.
• W2068592783 cites W1503499588 @default.
• W2068592783 cites W1503935526 @default.
• W2068592783 cites W1508127938 @default.
• W2068592783 cites W1576277997 @default.
• W2068592783 cites W1738081384 @default.
• W2068592783 cites W1802209367 @default.
• W2068592783 cites W1862827799 @default.
• W2068592783 cites W1965990720 @default.
• W2068592783 cites W1971358295 @default.
• W2068592783 cites W1971828356 @default.
• W2068592783 cites W1974706776 @default.
• W2068592783 cites W1975425686 @default.
• W2068592783 cites W1976992387 @default.
• W2068592783 cites W1984891060 @default.
• W2068592783 cites W1984893960 @default.
• W2068592783 cites W1987821255 @default.
• W2068592783 cites W1990382280 @default.
• W2068592783 cites W2000933955 @default.
• W2068592783 cites W2002694321 @default.
• W2068592783 cites W2008074642 @default.
• W2068592783 cites W2012682948 @default.
• W2068592783 cites W2015513895 @default.
• W2068592783 cites W2027074745 @default.
• W2068592783 cites W2032152886 @default.
• W2068592783 cites W2041216092 @default.
• W2068592783 cites W2042403486 @default.
• W2068592783 cites W2048680824 @default.
• W2068592783 cites W2056843713 @default.
• W2068592783 cites W2063212231 @default.
• W2068592783 cites W2070028948 @default.
• W2068592783 cites W2072690172 @default.
• W2068592783 cites W2075007350 @default.
• W2068592783 cites W2079625635 @default.
• W2068592783 cites W2083011228 @default.
• W2068592783 cites W2085578603 @default.
• W2068592783 cites W2090528265 @default.
• W2068592783 cites W2095161786 @default.
• W2068592783 cites W2116136260 @default.
• W2068592783 cites W2120492231 @default.
• W2068592783 cites W2126012718 @default.
• W2068592783 cites W2134273344 @default.
• W2068592783 cites W2135629133 @default.
• W2068592783 cites W2147200751 @default.
• W2068592783 cites W2151109481 @default.
• W2068592783 cites W2162685245 @default.
• W2068592783 cites W2173317214 @default.
• W2068592783 cites W2410772780 @default.
• W2068592783 cites W4378077911 @default.
• W2068592783 cites W632719117 @default.
• W2068592783 doi "https://doi.org/10.1111/epi.12403" @default.
• W2068592783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3995016" @default.
• W2068592783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24138281" @default.
• W2068592783 hasPublicationYear "2013" @default.
• W2068592783 type Work @default.
• W2068592783 sameAs 2068592783 @default.
• W2068592783 citedByCount "36" @default.
• W2068592783 countsByYear W20685927832014 @default.
• W2068592783 countsByYear W20685927832015 @default.
• W2068592783 countsByYear W20685927832016 @default.
• W2068592783 countsByYear W20685927832017 @default.
• W2068592783 countsByYear W20685927832018 @default.
• W2068592783 countsByYear W20685927832019 @default.
• W2068592783 countsByYear W20685927832020 @default.
• W2068592783 countsByYear W20685927832021 @default.
• W2068592783 countsByYear W20685927832022 @default.
• W2068592783 countsByYear W20685927832023 @default.
• W2068592783 crossrefType "journal-article" @default.
• W2068592783 hasAuthorship W2068592783A5049258088 @default.
• W2068592783 hasAuthorship W2068592783A5060298546 @default.
• W2068592783 hasAuthorship W2068592783A5074816207 @default.
• W2068592783 hasAuthorship W2068592783A5078902556 @default.
• W2068592783 hasBestOaLocation W20685927831 @default.
• W2068592783 hasConcept C105702510 @default.
• W2068592783 hasConcept C142724271 @default.
• W2068592783 hasConcept C148762608 @default.
• W2068592783 hasConcept C15744967 @default.
• W2068592783 hasConcept C169760540 @default.
• W2068592783 hasConcept C204232928 @default.
• W2068592783 hasConcept C2777127467 @default.
• W2068592783 hasConcept C2777209535 @default.
• W2068592783 hasConcept C2777597344 @default.
• W2068592783 hasConcept C2778186239 @default.
• W2068592783 hasConcept C2779134260 @default.
• W2068592783 hasConcept C2779246727 @default.
• W2068592783 hasConcept C2779740913 @default.
• W2068592783 hasConcept C2780130745 @default.
• W2068592783 hasConcept C2781099131 @default.
• W2068592783 hasConcept C2781161787 @default.

• next