Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068594576> ?p ?o ?g. }
- W2068594576 endingPage "220" @default.
- W2068594576 startingPage "212" @default.
- W2068594576 abstract "Chromosomal instability (CIN) is one of the common features in prostate cancer, especially in advanced stages. Recently, the involvement of p53 in CIN through the regulation of centrosome amplification has been proposed in certain tumor types. In this study, we investigated the relationship between p53 and centrosome amplification in prostate cancer cells. Increased centrosome number and size were observed in DU145 and PC3 containing nonfunctional p53 compared to LNCap which expressed wild-type p53. Transfection of p53 into PC3 cells resulted in a decreased cell growth rate, G2/M arrest and decreased centrosome abnormalities. We provide the first evidence on a correlation between loss of p53 function and centrosome amplification in prostate cancer cells. Our results indicate that p53 may play a role in the regulation of centrosome amplification and loss of p53 may be one of the mechanisms involving CIN in prostate cancer cells." @default.
- W2068594576 created "2016-06-24" @default.
- W2068594576 creator A5021521707 @default.
- W2068594576 creator A5024088442 @default.
- W2068594576 creator A5038876168 @default.
- W2068594576 creator A5054032752 @default.
- W2068594576 creator A5076820856 @default.
- W2068594576 creator A5090606171 @default.
- W2068594576 creator A5090696528 @default.
- W2068594576 date "2001-12-01" @default.
- W2068594576 modified "2023-10-01" @default.
- W2068594576 title "Effect of p53 on centrosome amplification in prostate cancer cells" @default.
- W2068594576 cites W12339002 @default.
- W2068594576 cites W1488637588 @default.
- W2068594576 cites W1657157395 @default.
- W2068594576 cites W1792024194 @default.
- W2068594576 cites W1975308167 @default.
- W2068594576 cites W1978528436 @default.
- W2068594576 cites W1991736202 @default.
- W2068594576 cites W2015998205 @default.
- W2068594576 cites W2018067226 @default.
- W2068594576 cites W2024143289 @default.
- W2068594576 cites W2034092995 @default.
- W2068594576 cites W2040154374 @default.
- W2068594576 cites W2043964688 @default.
- W2068594576 cites W2068121956 @default.
- W2068594576 cites W2080308138 @default.
- W2068594576 cites W2082589892 @default.
- W2068594576 cites W2085457796 @default.
- W2068594576 cites W2089685532 @default.
- W2068594576 cites W2090025028 @default.
- W2068594576 cites W2094798027 @default.
- W2068594576 cites W2095317270 @default.
- W2068594576 cites W2120435603 @default.
- W2068594576 cites W2128950990 @default.
- W2068594576 cites W2134397011 @default.
- W2068594576 cites W2138768698 @default.
- W2068594576 cites W2155954315 @default.
- W2068594576 cites W2321611063 @default.
- W2068594576 cites W2322441397 @default.
- W2068594576 cites W2328322198 @default.
- W2068594576 cites W2331626130 @default.
- W2068594576 cites W2415541861 @default.
- W2068594576 doi "https://doi.org/10.1016/s0167-4889(01)00157-4" @default.
- W2068594576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11755215" @default.
- W2068594576 hasPublicationYear "2001" @default.
- W2068594576 type Work @default.
- W2068594576 sameAs 2068594576 @default.
- W2068594576 citedByCount "24" @default.
- W2068594576 countsByYear W20685945762012 @default.
- W2068594576 countsByYear W20685945762014 @default.
- W2068594576 countsByYear W20685945762016 @default.
- W2068594576 countsByYear W20685945762019 @default.
- W2068594576 countsByYear W20685945762020 @default.
- W2068594576 crossrefType "journal-article" @default.
- W2068594576 hasAuthorship W2068594576A5021521707 @default.
- W2068594576 hasAuthorship W2068594576A5024088442 @default.
- W2068594576 hasAuthorship W2068594576A5038876168 @default.
- W2068594576 hasAuthorship W2068594576A5054032752 @default.
- W2068594576 hasAuthorship W2068594576A5076820856 @default.
- W2068594576 hasAuthorship W2068594576A5090606171 @default.
- W2068594576 hasAuthorship W2068594576A5090696528 @default.
- W2068594576 hasConcept C10447061 @default.
- W2068594576 hasConcept C121608353 @default.
- W2068594576 hasConcept C2776235491 @default.
- W2068594576 hasConcept C2776438761 @default.
- W2068594576 hasConcept C2779723316 @default.
- W2068594576 hasConcept C2780192828 @default.
- W2068594576 hasConcept C29537977 @default.
- W2068594576 hasConcept C502942594 @default.
- W2068594576 hasConcept C54009773 @default.
- W2068594576 hasConcept C54355233 @default.
- W2068594576 hasConcept C81885089 @default.
- W2068594576 hasConcept C86803240 @default.
- W2068594576 hasConcept C95444343 @default.
- W2068594576 hasConceptScore W2068594576C10447061 @default.
- W2068594576 hasConceptScore W2068594576C121608353 @default.
- W2068594576 hasConceptScore W2068594576C2776235491 @default.
- W2068594576 hasConceptScore W2068594576C2776438761 @default.
- W2068594576 hasConceptScore W2068594576C2779723316 @default.
- W2068594576 hasConceptScore W2068594576C2780192828 @default.
- W2068594576 hasConceptScore W2068594576C29537977 @default.
- W2068594576 hasConceptScore W2068594576C502942594 @default.
- W2068594576 hasConceptScore W2068594576C54009773 @default.
- W2068594576 hasConceptScore W2068594576C54355233 @default.
- W2068594576 hasConceptScore W2068594576C81885089 @default.
- W2068594576 hasConceptScore W2068594576C86803240 @default.
- W2068594576 hasConceptScore W2068594576C95444343 @default.
- W2068594576 hasIssue "3" @default.
- W2068594576 hasLocation W20685945761 @default.
- W2068594576 hasLocation W20685945762 @default.
- W2068594576 hasOpenAccess W2068594576 @default.
- W2068594576 hasPrimaryLocation W20685945761 @default.
- W2068594576 hasRelatedWork W2052103316 @default.
- W2068594576 hasRelatedWork W2096693293 @default.
- W2068594576 hasRelatedWork W2118642421 @default.
- W2068594576 hasRelatedWork W2366399622 @default.
- W2068594576 hasRelatedWork W2403366312 @default.