Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068596536> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2068596536 endingPage "1363" @default.
- W2068596536 startingPage "1359" @default.
- W2068596536 abstract "β-blockers are a class of drugs that are widely used in treating cardiac, respiratory and other ailments. They act by blocking β-adrenergic receptor-mediated signaling. Studies in various cancers have shown that patients taking a β-blocker have higher survival and lower recurrence and metastasis rates. This is supported by several preclinical and in vitro studies showing that adrenergic activation modulates apoptosis, promotes angiogenesis and other cancer hallmarks, and these effects can be abrogated by β-blockers. These studies provide a rationale for the use of β-blockers as adjuvants with cancer chemotherapy. However, all published studies so far are retrospective and most do not take into account the specific β-blocker used or address which is most likely to benefit cancer patients. The published epidemiological studies are correlative and have not examined the adrenergic receptor status of the tumors. Knowledge of the β-adrenergic receptor status of tumor cells is essential in choosing the best β-blocker for adjuvant therapy. A comprehensive, prospective study is necessary to definitively prove the utility of using β-blockers with chemotherapy and to identify the specific β-blocker most likely to benefit patients with cancer." @default.
- W2068596536 created "2016-06-24" @default.
- W2068596536 creator A5020081483 @default.
- W2068596536 creator A5071002527 @default.
- W2068596536 creator A5073591360 @default.
- W2068596536 creator A5075793477 @default.
- W2068596536 creator A5090920271 @default.
- W2068596536 date "2013-08-07" @default.
- W2068596536 modified "2023-09-30" @default.
- W2068596536 title "β-blockers: a new role in cancer chemotherapy?" @default.
- W2068596536 cites W1485843004 @default.
- W2068596536 cites W1963910752 @default.
- W2068596536 cites W2014334618 @default.
- W2068596536 cites W2050838989 @default.
- W2068596536 cites W2063506518 @default.
- W2068596536 cites W2076308201 @default.
- W2068596536 cites W2083977403 @default.
- W2068596536 cites W2111457041 @default.
- W2068596536 cites W2118147608 @default.
- W2068596536 cites W2132750237 @default.
- W2068596536 cites W2135451637 @default.
- W2068596536 cites W2139731996 @default.
- W2068596536 cites W2171415105 @default.
- W2068596536 cites W4239072443 @default.
- W2068596536 doi "https://doi.org/10.1517/13543784.2013.825250" @default.
- W2068596536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4143897" @default.
- W2068596536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23919278" @default.
- W2068596536 hasPublicationYear "2013" @default.
- W2068596536 type Work @default.
- W2068596536 sameAs 2068596536 @default.
- W2068596536 citedByCount "24" @default.
- W2068596536 countsByYear W20685965362015 @default.
- W2068596536 countsByYear W20685965362016 @default.
- W2068596536 countsByYear W20685965362017 @default.
- W2068596536 countsByYear W20685965362018 @default.
- W2068596536 countsByYear W20685965362019 @default.
- W2068596536 countsByYear W20685965362021 @default.
- W2068596536 countsByYear W20685965362022 @default.
- W2068596536 countsByYear W20685965362023 @default.
- W2068596536 crossrefType "journal-article" @default.
- W2068596536 hasAuthorship W2068596536A5020081483 @default.
- W2068596536 hasAuthorship W2068596536A5071002527 @default.
- W2068596536 hasAuthorship W2068596536A5073591360 @default.
- W2068596536 hasAuthorship W2068596536A5075793477 @default.
- W2068596536 hasAuthorship W2068596536A5090920271 @default.
- W2068596536 hasBestOaLocation W20685965361 @default.
- W2068596536 hasConcept C121608353 @default.
- W2068596536 hasConcept C126322002 @default.
- W2068596536 hasConcept C143998085 @default.
- W2068596536 hasConcept C2776694085 @default.
- W2068596536 hasConcept C2779013556 @default.
- W2068596536 hasConcept C2780394083 @default.
- W2068596536 hasConcept C71924100 @default.
- W2068596536 hasConcept C98274493 @default.
- W2068596536 hasConceptScore W2068596536C121608353 @default.
- W2068596536 hasConceptScore W2068596536C126322002 @default.
- W2068596536 hasConceptScore W2068596536C143998085 @default.
- W2068596536 hasConceptScore W2068596536C2776694085 @default.
- W2068596536 hasConceptScore W2068596536C2779013556 @default.
- W2068596536 hasConceptScore W2068596536C2780394083 @default.
- W2068596536 hasConceptScore W2068596536C71924100 @default.
- W2068596536 hasConceptScore W2068596536C98274493 @default.
- W2068596536 hasIssue "11" @default.
- W2068596536 hasLocation W20685965361 @default.
- W2068596536 hasLocation W20685965362 @default.
- W2068596536 hasLocation W20685965363 @default.
- W2068596536 hasLocation W20685965364 @default.
- W2068596536 hasOpenAccess W2068596536 @default.
- W2068596536 hasPrimaryLocation W20685965361 @default.
- W2068596536 hasRelatedWork W2049739326 @default.
- W2068596536 hasRelatedWork W2103824592 @default.
- W2068596536 hasRelatedWork W2118310713 @default.
- W2068596536 hasRelatedWork W2358524972 @default.
- W2068596536 hasRelatedWork W2367334623 @default.
- W2068596536 hasRelatedWork W2950257663 @default.
- W2068596536 hasRelatedWork W2968900310 @default.
- W2068596536 hasRelatedWork W3029901370 @default.
- W2068596536 hasRelatedWork W4232765479 @default.
- W2068596536 hasRelatedWork W75273126 @default.
- W2068596536 hasVolume "22" @default.
- W2068596536 isParatext "false" @default.
- W2068596536 isRetracted "false" @default.
- W2068596536 magId "2068596536" @default.
- W2068596536 workType "article" @default.