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- W2068596912 abstract "We tested the hypothesis of whether high dietary protein intake is linked to oxidative stress as measured by the concentration of reactive carbonyl residues in plasma proteins. Three groups of male Wistar rats (∼230 g, n = 10) were fed either 15% (15C), 30% (30C), or 60% (60C) casein diets over a period of 18 weeks. For comparison, a vitamin E deficient diet (60C-E) based on diet 60C was given to an additional group to provoke oxidative stress. Concentrations of α-tocopherol in plasma and of reactive carbonyl residues in total plasma proteins were measured by high performance liquid chromatography using fluorescence and by diode array detection after 2,4-dinitrophenylhydrazine reaction, respectively. After 1 week the concentration of reactive carbonyl residues in plasma proteins was found to be significantly (P < 0.05) higher in the 60C and 60C-E groups (∼2.7 nmol/mg protein) compared with the 15C and 30C groups (∼1.7 nmol/mg protein). After 14 weeks the 15C (3.4 ± 1.2 nmol/mg protein) and 60C-E groups (3.9 ± 1.7 nmol/mg protein) showed a significantly increased concentration of reactive carbonyl residues in plasma protein compared with the 30C and 60C groups (2.5 ± 1.0 nmol/mg protein; 2.6 ± 0.8 nmol/mg protein). As expected, chronic vitamin E deficiency (60C-E) resulted in significantly decreased α-tocopherol concentrations (3.91 ± 2.42 μmol/mL vs. 31.3 ± 4.8 μmol/mL) and a higher concentration of reactive carbonyl residues in plasma proteins. These results do not support the hypothesis that a chronic intake of high-protein diets leads to oxidative stress in adult rats. However, in the non-adapted state (1 week) a high protein intake contributes to oxidative modifications of protein-bound amino acid residues." @default.
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- W2068596912 date "1999-05-01" @default.
- W2068596912 modified "2023-09-24" @default.
- W2068596912 title "Plasma protein carbonyl concentration is not enhanced by chronic intake of high-protein diets in adult rats" @default.
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- W2068596912 doi "https://doi.org/10.1016/s0955-2863(99)00006-6" @default.
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