FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068597369> ?p ?o ?g. }

• W2068597369 endingPage "g1888" @default.
• W2068597369 startingPage "g1888" @default.
• W2068597369 abstract "<b>Objective</b> To systematically review published and unpublished efficacy studies of agomelatine in people with depression. <b>Design</b> Systematic review and meta-analysis. <b>Data sources</b> Literature search (Pubmed, Embase, Medline), Cochrane Central Register of Controlled Trials, European Medicines Agency (EMA) regulatory file for agomelatine, manufacturers of agomelatine (Servier). <b>Eligibility criteria</b> Double blind randomised placebo and comparator controlled trials of agomelatine in depression with standard depression rating scales. <b>Data synthesis</b> Studies were pooled by using a random effects model with DerSimonian and Laird weights for comparisons with placebo and comparator antidepressant. The primary efficacy measure (change in rating scale score) was summarised with standardised mean difference (SMD; a measure of effect size) and secondary outcome measures with relative risks. All results were presented with 95% confidence intervals. Statistical heterogeneity was explored by visual inspection of funnel plots and by the I² statistic. Moderators of effect were explored by meta-regression. <b>Results</b> We identified 20 trials with 7460 participants meeting inclusion criteria (11 in the published literature, four from the European Medicines Agency file, and five from the manufacturer). Almost all studies used the 17 item Hamilton depression rating scale (score 0-50). Agomelatine was significantly more effective than placebo with an effect size (SMD) of 0.24 (95% confidence interval 0.12 to 0.35) and relative risk of response 1.25 (1.11 to 1.4). Compared with other antidepressants, agomelatine showed equal efficacy (SMD 0.00, −0.09 to 0.10). Significant heterogeneity was uncovered in most analyses, though risk of bias was low. Published studies were more likely than unpublished studies to have results that suggested advantages for agomelatine. <b>Conclusions</b> Agomelatine is an effective antidepressant with similar efficacy to standard antidepressants. Published trials generally had more favourable results than unpublished studies." @default.
• W2068597369 created "2016-06-24" @default.
• W2068597369 creator A5014436895 @default.
• W2068597369 creator A5015061085 @default.
• W2068597369 creator A5072094702 @default.
• W2068597369 creator A5089504924 @default.
• W2068597369 date "2014-03-19" @default.
• W2068597369 modified "2023-10-18" @default.
• W2068597369 title "Antidepressant efficacy of agomelatine: meta-analysis of published and unpublished studies" @default.
• W2068597369 cites W1894568551 @default.
• W2068597369 cites W1904816587 @default.
• W2068597369 cites W1976410377 @default.
• W2068597369 cites W1977708183 @default.
• W2068597369 cites W1982665253 @default.
• W2068597369 cites W1988123141 @default.
• W2068597369 cites W1992439764 @default.
• W2068597369 cites W1994849630 @default.
• W2068597369 cites W2003982930 @default.
• W2068597369 cites W2005097746 @default.
• W2068597369 cites W2005935080 @default.
• W2068597369 cites W2006272001 @default.
• W2068597369 cites W2013372440 @default.
• W2068597369 cites W2020001299 @default.
• W2068597369 cites W2022032351 @default.
• W2068597369 cites W2022992308 @default.
• W2068597369 cites W2030270520 @default.
• W2068597369 cites W2045543396 @default.
• W2068597369 cites W2045614420 @default.
• W2068597369 cites W2046271238 @default.
• W2068597369 cites W2046391772 @default.
• W2068597369 cites W2046456811 @default.
• W2068597369 cites W2058816028 @default.
• W2068597369 cites W2059735897 @default.
• W2068597369 cites W2062836608 @default.
• W2068597369 cites W2086546977 @default.
• W2068597369 cites W2098687045 @default.
• W2068597369 cites W2098923148 @default.
• W2068597369 cites W2101652281 @default.
• W2068597369 cites W2101832118 @default.
• W2068597369 cites W2114613490 @default.
• W2068597369 cites W2116153150 @default.
• W2068597369 cites W2120729007 @default.
• W2068597369 cites W2126194308 @default.
• W2068597369 cites W2128478870 @default.
• W2068597369 cites W2131823335 @default.
• W2068597369 cites W2132270063 @default.
• W2068597369 cites W2141979672 @default.
• W2068597369 cites W2147406359 @default.
• W2068597369 cites W2153403353 @default.
• W2068597369 cites W2161185297 @default.
• W2068597369 cites W2220387563 @default.
• W2068597369 cites W2317945617 @default.
• W2068597369 cites W2588681363 @default.
• W2068597369 cites W4250750484 @default.
• W2068597369 doi "https://doi.org/10.1136/bmj.g1888" @default.
• W2068597369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3959623" @default.
• W2068597369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24647162" @default.
• W2068597369 hasPublicationYear "2014" @default.
• W2068597369 type Work @default.
• W2068597369 sameAs 2068597369 @default.
• W2068597369 citedByCount "302" @default.
• W2068597369 countsByYear W20685973692013 @default.
• W2068597369 countsByYear W20685973692014 @default.
• W2068597369 countsByYear W20685973692015 @default.
• W2068597369 countsByYear W20685973692016 @default.
• W2068597369 countsByYear W20685973692017 @default.
• W2068597369 countsByYear W20685973692018 @default.
• W2068597369 countsByYear W20685973692019 @default.
• W2068597369 countsByYear W20685973692020 @default.
• W2068597369 countsByYear W20685973692021 @default.
• W2068597369 countsByYear W20685973692022 @default.
• W2068597369 countsByYear W20685973692023 @default.
• W2068597369 crossrefType "journal-article" @default.
• W2068597369 hasAuthorship W2068597369A5014436895 @default.
• W2068597369 hasAuthorship W2068597369A5015061085 @default.
• W2068597369 hasAuthorship W2068597369A5072094702 @default.
• W2068597369 hasAuthorship W2068597369A5089504924 @default.
• W2068597369 hasBestOaLocation W20685973691 @default.
• W2068597369 hasConcept C105795698 @default.
• W2068597369 hasConcept C118552586 @default.
• W2068597369 hasConcept C119423318 @default.
• W2068597369 hasConcept C126322002 @default.
• W2068597369 hasConcept C139719470 @default.
• W2068597369 hasConcept C142724271 @default.
• W2068597369 hasConcept C162324750 @default.
• W2068597369 hasConcept C204787440 @default.
• W2068597369 hasConcept C27081682 @default.
• W2068597369 hasConcept C2776466505 @default.
• W2068597369 hasConcept C2776867660 @default.
• W2068597369 hasConcept C2779177272 @default.
• W2068597369 hasConcept C2780051608 @default.
• W2068597369 hasConcept C2780439572 @default.
• W2068597369 hasConcept C2780733359 @default.
• W2068597369 hasConcept C2780798758 @default.
• W2068597369 hasConcept C2781161787 @default.
• W2068597369 hasConcept C33923547 @default.
• W2068597369 hasConcept C44249647 @default.
• W2068597369 hasConcept C535046627 @default.

• next