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• W2068598206 abstract "Abstract Folates and folate-like molecules represent a class of vectors for drug targeting and delivery. The folate receptor (FR) is overexpressed in many human cancers, therefore folate-cytotoxic drug conjugates can deliver therapeutic agents specifically to FR positive tumours. We have linked, directly through one of the carboxylate functionalities of the folic acid (α or γ), two different chelating arms for a cytotoxic platinum moiety, namely a diamine and a dicarboxylate. Five different derivatives were synthesised by multi-step procedures, purified and characterised; unfortunately, they resulted barely soluble in water, thereby precluding any biochemical and biological tests." @default.
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• W2068598206 date "2008-04-01" @default.
• W2068598206 modified "2023-10-11" @default.
• W2068598206 title "Stepwise assembly of platinum–folic acid conjugates" @default.
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• W2068598206 doi "https://doi.org/10.1016/j.ica.2007.09.020" @default.
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