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- W2068598910 abstract "Recent advances in T cell biology have shed light on the role of T cell subsets in the pathogenesis of acute kidney injury (AKI). The purpose of this review is to harness our understanding of recent advances in T cell biology in tissue injury and repair and provide a mechanistic insight into the role of T cells in the inflammation of AKI.New specific reagents and genetic animal models have led to advances in our understanding of the role of T cell subsets involved in renal injury. Whereas some T cells promote innate renal inflammation and injury, other T cells promote protection and repair. Recent studies illuminated the pathogenic mechanisms of invariant natural killer T (NKT) cells and T helper1-type responses, and the beneficial functions of regulatory T cells and NKT cells are just beginning to be explored. Pharmacologic and cell-based therapies that influence T cell responses to experimental AKI suggest that this is a promising approach to preserve renal function.The recent insights gained into how T cells modulate renal injury suggest that strategies targeting specific types of T cells, to either inhibit or enhance their activity, may ameliorate renal injury in patients." @default.
- W2068598910 created "2016-06-24" @default.
- W2068598910 creator A5043847672 @default.
- W2068598910 creator A5072442015 @default.
- W2068598910 date "2014-01-01" @default.
- W2068598910 modified "2023-10-13" @default.
- W2068598910 title "Expanding role of T cells in acute kidney injury" @default.
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- W2068598910 doi "https://doi.org/10.1097/01.mnh.0000436695.29173.de" @default.
- W2068598910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3909711" @default.
- W2068598910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24231312" @default.
- W2068598910 hasPublicationYear "2014" @default.
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