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• W2068600166 abstract "α-, β-, γ-, and δ-Sarcoglycans (SGs) are transmembrane glycoprotein components of the dystrophin-associated protein (DAP) complex, which is critical for the stability of the striated muscle cell membrane. ε-SG was found as a homologue of α-SG, but unlike other SG members, it is ubiquitously expressed in various tissues as well as in striated muscle. Moreover, mutations in the ε-SG gene cause myoclonus-dystonia, indicating the importance of ε-SG for the function in the central nervous system. To gain insight into the role of ε-SG, its expression and subcellular distribution in mouse tissues and especially in the mouse brain were investigated. Analysis by reverse transcription-polymerase chain reaction showed four splice variants of ε-SG transcripts in the mouse brain, two of which are major transcript forms. One is a conventional form including exon 8 (ε-SG1), and the other is a novel form excluding exon 8 but including a previously unknown exon, 11b (ε-SG2). Immunoblot analysis using various mouse tissues indicated a broad expression pattern for ε-SG1, but ε-SG2 was expressed exclusively in the brain. Therefore, both ε-SG isoforms coexist in various regions of the brain. Furthermore, these isoforms were found in neuronal cells using immunohistochemical analysis. Subcellular fractionation of brain homogenates, however, indicated that ε-SG1 and ε-SG2 are relatively enriched in post- and pre-synaptic membrane fractions, respectively. These results suggest that the two ε-SG isoforms might play different roles in synaptic functions of the central nervous system." @default.
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• W2068600166 date "2004-06-01" @default.
• W2068600166 modified "2023-09-26" @default.
• W2068600166 title "Identification and characterization of ε-sarcoglycans in the central nervous system" @default.
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• W2068600166 doi "https://doi.org/10.1016/j.molbrainres.2004.01.012" @default.
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