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- W2068600730 abstract "In 1954, less than 10 years after penicillin came into general use and had been shown to be an exceedingly effective drug against streptococcal infection in children, Maclyn McCarty1voiced the following warning: The extensive use of penicillin throughout childhood may ultimately result in an adult population with a susceptibility to streptococcal disease comparable to that kind we find in school children. This warning was based on the observation that treatment with penicillin interfered with the development of type-specific immunity, which is considered to be the foundation of adult immunity to streptococcal infection. Since the basic studies of Denny, Wannamaker, Brink, Rammelkamp, and Custer2indicate that prevention of rheumatic fever can be attained by adequate therapy of the initial streptococcal infection with penicillin, this leaves the physician between the horns of a dilemma. If he treats streptococcal infections adequately he interferes with the development of type-specific immunity. If" @default.
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- W2068600730 date "1960-09-01" @default.
- W2068600730 modified "2023-10-18" @default.
- W2068600730 title "The Prevention of Type Specific Immunity to Streptococcal Infections Due to the Therapeutic Use of Penicillin" @default.
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- W2068600730 doi "https://doi.org/10.1001/archpedi.1960.04020040355007" @default.
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