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- W2068604073 abstract "Background: Relationships between heart rate (HR) variability and different prognostic markers such as ejection fraction, functional capacity, and patency of the infarct-related artery, as well as the comparison of their time courses are not fully elucidated. Hypothesis: The aim of study was to assess prospectively the early postinfarction changes in HR variability and its evolution over a period of 6 months; the relationships between HR variability and functional capacity in exercise testing; left ventricular function in cardiac catheterization; status of the infarct-related artery; and the comparison of their time courses. Methods: In 42 patients with anterior myocardial infarction. a study was made of the early changes in HR variability analyzed by the complex demodulation method, its evolution over a period of 6 months, and the relationships between HR variability and (1) functional capacity in exercise testing, (2) left ventricular function in cardiac catheterization, and (3) status of the infarct-related artery. Results: At 1 week HR variability parameters correlated directly with functional capacity indicators such as METS, percent change in HR from rest to peak exercise (% H̊), difference between initial and peak HR (HR range), percent peak theoretical HR (% peak HR), left ventricular ejection fraction (EF), and, inversely, with end-systolic volume (ESV). Stepwise multiple regression analysis to establish HR variability parameters (recorded at 1 week) as related to functional capacity and left ventricular function at 1 week and 6 months postinfarction established the following variables: (1) At 1 week: standard deviation (SD) of the RR cycles in relation to % H̊ (r = 0.60, p < 0.0001), HR range (r = 0.43, p < 0.01), and EF (r = 0.79, p < 0.0001). (2) At 6 months, the sole accepted HR variability parameter was the SD in relation to %<ΔH̊ (r = 0.38, p<0.05) and HR range (r=0.45, p <0.01). No variability parameter was accepted in relation to METS, % peak HR, or ESV. Relationship between EF or ESV and HR variability parameters was not significant when both were evaluated at 6 months. At that time, there was a significant increase in all HR variability parameters among all surviving patients (n = 39), with the exception of the LF/HF ratio and mean RR cycle. The percent increase in HR variability between the first week and 6 months was greater among those patients with the lowest basal EF. No relation was established between HR variability and patency of the infarct-related artery. Conclusion: The decrease in HR variability observed following myocardial infarction is associated with a diminished functional capacity and an increased alteration of the EF. This does not affect the recovery of HR variability, which was observed in all surviving patients." @default.
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- W2068604073 title "Relationships between heart rate variability, functional capacity, and left ventricular function following myocardial infarction: An evaluation after one week and six months" @default.
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- W2068604073 doi "https://doi.org/10.1002/clc.4960240411" @default.
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