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- W2068606301 abstract "Introduction: The association between gastroesophageal reflux (GER), laryngopharyngeal reflux (LPR) and laryngeal disorders in children is still debated. Aims of our study were: a) to assess whether LPR may be responsible of respiratory symptoms and b) to identify those parameters of pH monitoring predictive of laryngeal involvement. Methods: 32 consecutive children [20 M; median age 4,11 y (range: 3,4–11 y)] referred to us with upper airway disorders (chronic cough, laryngitis, dysphonia, ear diseases) of idiopathic nature were evaluated. All underwent: a) a complete otorhino-laryngologic evaluation (otological examination, rhino-pharyngoscopy, laryngoscopy) and b) pharyngoesophageal 24-hour pH monitoring. Laryngeal involvement was scored in S0 (no disease), S1 (mild hyperaemia extended to proximal larynx), S2 (hyperaemia extended to distal larynx) and S3 (hypertrophy and granuloma). GER and LPR were diagnosed in presence of a distal reflux index (RI) greater than 5% and a number of proximal reflux episodes greater than 10, respectively. Results: GER occurred in 12/32 children (38%). No clear association was found between GER, LPR and pathologic findings of ear, nose and pharynx. Children with laryngeal involvement (LI) (n:17) had a greater RI and a longer acid clearance time (ACT) both at proximal (1,7 vs. 0,6; p<0.01 − 2,5 vs. 1; p<0.001) and distal (5,4 vs. 1,8; p<0.01 − 2,6 vs. 1,3; p<0.002) electrode, as compared to children without laryngeal disease. Interestingly, most reflux episodes occurred in up-right position. We found a positive correlation between RI, ACT and LI (p<0.04; p<0.001 respectively). Conclusion: This study shows that GER and mainly LPR are associated with laryngeal diseases. Therefore, a 24 hours pH study may be of great help in the differential diagnosis of children with respiratory tract symptoms idiopathic in nature." @default.
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- W2068606301 date "2004-06-01" @default.
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- W2068606301 title "P1049 DOUBLE PROBE PH MONITORING IN CHILDREN WITH OTORHINO-LARYNGOLOGICAL SYMPTOMS" @default.
- W2068606301 doi "https://doi.org/10.1097/00005176-200406001-01173" @default.
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