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- W2068607816 abstract "Pigeons were made tolerant to the behavioral effects of 1-Δ9-trans-tetrahydrocannabinol (Δ9-THC) by repeated intramuscular injections. The tolerant birds, as well as birds that had no received Δ9-THC previously, were injected with 3H-Δ9-THC and blood samples were drawn over a period from 1 min to 2 weeks after injection. High levels of radioactivity appeared in the blood 1 min after injection and peak levels were reached in 30 min, after which there was a gradual decline with some radioactivity still present after 2 weeks. The levels of radioactivity in the petroleum ether-extractable fraction [mostly Δ9-THC by thin-layer chromatography (TLC)], in the diethyl ether- extractable fraction (mostly hydroxylated metabolites by TLC), and in the residue fraction of the plasma were also determined over the 2-week period. There were no differences between tolerant and nontolerant birds in levels of radioactivity in total plasma, or in any of the plasma fractions. In other experiments, seven injections of 3H-δ9-THC were given to pigeons over a 2-week period during which behavioral tolerance developed. Radioactivity gradually accumulated in the plasma of these birds; however, most of the radioactivity was accounted for in the residue fraction, with levels of radioactivity in the petroleum ether-extractable fraction and the diethyl ether-extractable fractions remaining at about the same levels after seven injections as after one injection. These results suggest that tolerant birds handle an injection of δ9-THC in much the same manner as nontolerant birds, and that levels of δ9-THC and its metabolites are as high as or higher in the blood of tolerant birds than they are in the blood of nontolerant birds. Thus, tolerance to δ9-THC in the pigeon does not appear to be metabolic in origin." @default.
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- W2068607816 date "1973-02-01" @default.
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- W2068607816 title "Blood levels of 3H-Δ9-tetrahydrocannabinol and its metabolites in tolerant and nontolerant pigeons" @default.
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- W2068607816 doi "https://doi.org/10.1016/0006-2952(73)90419-x" @default.
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