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• W2068608123 abstract "The United States is currently experiencing an entangled epidemic of HIV infection and use of different drugs of abuse, especially of methamphetamine (Meth). Blood monocyte-derived dendritic cells (DC) are the first line of defense against HIV-1 infection, and are the initial target of HIV-1 infection in injection drug users. DC-SIGN present on dendritic cells is the first molecule that facilitates HIV-1 infection independent of CD4 or HIV coreceptors.The aim of this study was to evaluate whether Meth acts as a cofactor in the pathogenesis of HIV-1 infection.Monocyte derived DCs, obtained from normal subjects were cultured with and without Meth±HIV-1B, followed by analyzing the gene and protein expression by real-time quantitative polymerase chain reaction (RT-PCR) and fluorescence-activated cell-sorting analyses, respectively.Our results show that Meth significantly enhances HIV infection, and downregulates the gene expression of chemokines and costimulatory molecules with reciprocal upregulation of HIV coreceptors and DC-SIGN by dendritic cells.Better understanding of the role of Meth in HIV-1 disease susceptibility and the mechanism through which Meth mediates its effects on HIV-1 infection may help to devise novel therapeutic strategies against HIV-1 infection in Meth using HIV-1 infected population." @default.
• W2068608123 created "2016-06-24" @default.
• W2068608123 creator A5047076583 @default.
• W2068608123 creator A5065693734 @default.
• W2068608123 date "2011-05-01" @default.
• W2068608123 modified "2023-09-27" @default.
• W2068608123 title "Effect of methamphetamine on expression of HIV coreceptors and CC-chemokines by dendritic cells" @default.
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• W2068608123 doi "https://doi.org/10.1016/j.lfs.2010.09.019" @default.
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