FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068608662> ?p ?o ?g. }

• W2068608662 endingPage "344" @default.
• W2068608662 startingPage "335" @default.
• W2068608662 abstract "In contrast to the autoprocessing of caspase-9, little is known about the biological significance of caspase-9 processing by caspase-3 via a feedback loop in vivo. We prepared antisera against mouse caspase-9 cleavage sites so that only the activated form of mouse caspase-9 was recognized. Using these antisera and caspase-9- and caspase-3-deficient mouse embryonic fibroblasts, we demonstrated that mouse caspase-9 is initially autoprocessed at D(353) and D(368) at low levels during staurosporine-induced apoptosis, whereupon the D(368) and D(168) sites are preferentially processed over D(353) by activated caspase-3 as part of a feedback amplification loop. Ac-DEVD-MCA (caspase-3-like) and Ac-LEHD-MCA (caspase-9-like) cleavage activities clearly showed that caspase-9 autoprocessing was necessary for the activation of caspase-3, whereas full activation of caspase-3 and caspase-9 was achieved only through the feedback amplification loop. This feedback amplification loop also played a predominant role during programmed cell death of dorsal root ganglia neurons at mouse embryonic day 11.5." @default.
• W2068608662 created "2016-06-24" @default.
• W2068608662 creator A5001883766 @default.
• W2068608662 creator A5007698785 @default.
• W2068608662 creator A5039446349 @default.
• W2068608662 creator A5044641518 @default.
• W2068608662 creator A5081746538 @default.
• W2068608662 date "2001-04-01" @default.
• W2068608662 modified "2023-10-18" @default.
• W2068608662 title "Caspase-9 processing by caspase-3 via a feedback amplification loop in vivo" @default.
• W2068608662 cites W1500396877 @default.
• W2068608662 cites W1506642042 @default.
• W2068608662 cites W1965372133 @default.
• W2068608662 cites W1969133624 @default.
• W2068608662 cites W1980638710 @default.
• W2068608662 cites W1987785848 @default.
• W2068608662 cites W1992320660 @default.
• W2068608662 cites W1995463051 @default.
• W2068608662 cites W2000352412 @default.
• W2068608662 cites W2005170991 @default.
• W2068608662 cites W2010243701 @default.
• W2068608662 cites W2013685285 @default.
• W2068608662 cites W2026692684 @default.
• W2068608662 cites W2026761074 @default.
• W2068608662 cites W2032763419 @default.
• W2068608662 cites W2049873418 @default.
• W2068608662 cites W2061497413 @default.
• W2068608662 cites W2072502723 @default.
• W2068608662 cites W2072858020 @default.
• W2068608662 cites W2083560313 @default.
• W2068608662 cites W2085601531 @default.
• W2068608662 cites W2086493438 @default.
• W2068608662 cites W2087450028 @default.
• W2068608662 cites W2090161008 @default.
• W2068608662 cites W2090414390 @default.
• W2068608662 cites W2094126824 @default.
• W2068608662 cites W2119683782 @default.
• W2068608662 cites W2120473562 @default.
• W2068608662 cites W2138302361 @default.
• W2068608662 cites W2144701362 @default.
• W2068608662 cites W2157999078 @default.
• W2068608662 cites W2320890190 @default.
• W2068608662 cites W2328367416 @default.
• W2068608662 cites W2333003336 @default.
• W2068608662 doi "https://doi.org/10.1038/sj.cdd.4400824" @default.
• W2068608662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11550085" @default.
• W2068608662 hasPublicationYear "2001" @default.
• W2068608662 type Work @default.
• W2068608662 sameAs 2068608662 @default.
• W2068608662 citedByCount "102" @default.
• W2068608662 countsByYear W20686086622012 @default.
• W2068608662 countsByYear W20686086622013 @default.
• W2068608662 countsByYear W20686086622014 @default.
• W2068608662 countsByYear W20686086622015 @default.
• W2068608662 countsByYear W20686086622016 @default.
• W2068608662 countsByYear W20686086622017 @default.
• W2068608662 countsByYear W20686086622018 @default.
• W2068608662 countsByYear W20686086622020 @default.
• W2068608662 countsByYear W20686086622021 @default.
• W2068608662 countsByYear W20686086622022 @default.
• W2068608662 countsByYear W20686086622023 @default.
• W2068608662 crossrefType "journal-article" @default.
• W2068608662 hasAuthorship W2068608662A5001883766 @default.
• W2068608662 hasAuthorship W2068608662A5007698785 @default.
• W2068608662 hasAuthorship W2068608662A5039446349 @default.
• W2068608662 hasAuthorship W2068608662A5044641518 @default.
• W2068608662 hasAuthorship W2068608662A5081746538 @default.
• W2068608662 hasBestOaLocation W20686086621 @default.
• W2068608662 hasConcept C104317684 @default.
• W2068608662 hasConcept C12519072 @default.
• W2068608662 hasConcept C145103041 @default.
• W2068608662 hasConcept C153911025 @default.
• W2068608662 hasConcept C155863897 @default.
• W2068608662 hasConcept C176912530 @default.
• W2068608662 hasConcept C185592680 @default.
• W2068608662 hasConcept C190283241 @default.
• W2068608662 hasConcept C195794163 @default.
• W2068608662 hasConcept C2775998712 @default.
• W2068608662 hasConcept C2779084600 @default.
• W2068608662 hasConcept C31573885 @default.
• W2068608662 hasConcept C48297814 @default.
• W2068608662 hasConcept C55493867 @default.
• W2068608662 hasConcept C62478195 @default.
• W2068608662 hasConcept C86803240 @default.
• W2068608662 hasConcept C95444343 @default.
• W2068608662 hasConcept C98424977 @default.
• W2068608662 hasConceptScore W2068608662C104317684 @default.
• W2068608662 hasConceptScore W2068608662C12519072 @default.
• W2068608662 hasConceptScore W2068608662C145103041 @default.
• W2068608662 hasConceptScore W2068608662C153911025 @default.
• W2068608662 hasConceptScore W2068608662C155863897 @default.
• W2068608662 hasConceptScore W2068608662C176912530 @default.
• W2068608662 hasConceptScore W2068608662C185592680 @default.
• W2068608662 hasConceptScore W2068608662C190283241 @default.
• W2068608662 hasConceptScore W2068608662C195794163 @default.
• W2068608662 hasConceptScore W2068608662C2775998712 @default.
• W2068608662 hasConceptScore W2068608662C2779084600 @default.
• W2068608662 hasConceptScore W2068608662C31573885 @default.

• next