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• W2068608995 abstract "In Brief Objective: The objective of this study was to determine herpes simplex virus type 2 (HSV-2) seroprevalence at HIV-1 diagnosis and seroincidence ≥1 year after HIV-1 diagnosis. Methods: HSV type-specific antibodies were detected by enzyme immunoassay. Results: The cohort comprised 850 adults diagnosed HIV-positive in 1986–2001 and followed for a median of 3 years. HSV-2 seroprevalence was 63% (95% confidence interval [CI], 60–66%) and was associated with female gender, heterosexual risk group, black ethnicity, and older age. HSV-2 seroincidence was 1.8 per 100 person-years (95% CI, 0.8–2.8) and was associated with other sexually transmitted diseases, including human papilloma virus infection (P = 0.005) and gonorrhea (P = 0.05). A diagnosis of genital herpes was made in 21% HSV-2-seropositive persons and was more likely in those who tested HIV-positive before 1997 (adjusted odds ratio, 5.11; 95% CI, 3.28–7.98; P = 0.0001). Conclusions: Results confirm the epidemiologic association between HIV-1 and HSV-2. HSV-2 seroconversion was a marker of high-risk sexual behavior. The likelihood of developing symptoms of genital herpes declined from 1997 onward. In a cohort of HIV-infected persons, herpes simplex virus type 2 (HSV-2) seroprevalence at HIV diagnosis was predicted by gender, age, ethnicity, and risk group. HSV-2 seroconversion after HIV diagnosis was associated with other sexually transmitted diseases." @default.
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• W2068608995 date "2006-02-01" @default.
• W2068608995 modified "2023-09-27" @default.
• W2068608995 title "Herpes Simplex Virus Type 2 (HSV-2) Seroprevalence at the Time of HIV-1 Diagnosis and Seroincidence After HIV-1 Diagnosis in an Ethnically Diverse Cohort of HIV-1-Infected Persons" @default.
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• W2068608995 doi "https://doi.org/10.1097/01.olq.0000187211.61052.c7" @default.
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