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- W2068609671 abstract "The human brain is the most complex structure encounteredby natural science. This structure is made up of B1 trillionneural cells that form an intricate web of innumerableconnections, which form the substrate for informationprocessing. These connections are of fundamental impor-tance because brain function lies in communications that areshaped by the environment and experience. Neural tissue isintrinsically plastic, and neural circuitry is constantly rewiredand remodelled. Plasticity of the brain is controlled at threeinterdependent levels: in subcellular compartments, at thelevel of single cells and at the level of cellular networks. At alllevels, however, signalling imbalance may cause toxicity,damage and death of neural elements, which in turncompromise communication processes within the neuralweb, thus causing neurological disease. Evidence is accu-mulating that the disruption of connectivity within neuralcircuits, loss of synapses and deteriorated synaptic plasticityprecede death of neurones, and that this is fundamentalpathologically to our understanding of neurodegeneration isaccumulating.Thesynapticdeficitsprecedeplaqueformationand brain atrophy in Alzheimer’s disease, and in a ratglaucoma model loss of synaptic activity occurs beforedemise of retinal ganglion cells." @default.
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- W2068609671 date "2010-06-14" @default.
- W2068609671 modified "2023-10-18" @default.
- W2068609671 title "Neurodegenerative diseases: failures in brain connectivity?" @default.
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- W2068609671 doi "https://doi.org/10.1038/cdd.2010.23" @default.
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