Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068617275> ?p ?o ?g. }
- W2068617275 endingPage "11" @default.
- W2068617275 startingPage "1" @default.
- W2068617275 abstract "Phospholipases A(2) (PLA(2)s) with a lysine substituting for the highly conserved aspartate 49, Lys49 PLA(2) homologues, are important myotoxic components in venoms from snakes of Viperidae family. These proteins induce conspicuous myonecrosis by a catalytically-independent mechanism. Traditionally, the Lys49 PLA(2) homologues are classified as non-neurotoxic myotoxins given their inability to cause lethality or paralytic effects when injected in vivo, even at relatively high doses. However, a series of in vitro studies has shown that several Lys49 PLA(2) homologues from Bothrops snake venoms induce neuromuscular blocking activity on nerve-muscle preparations in vitro. The interpretation of these findings has created some confusion in the literature, raising the question whether the Lys49 PLA(2) homologues present some neurotoxic activity. The present article reviews the in vitro neuromuscular effects of Lys49 PLA(2) homologues and discusses their possible mechanisms of action. It was concluded that the neuromuscular blockade induced by Lys49 PLA(2) homologues in isolated preparations is mainly a consequence of the general membrane-destabilizing effect of these toxins." @default.
- W2068617275 created "2016-06-24" @default.
- W2068617275 creator A5047513934 @default.
- W2068617275 creator A5052232205 @default.
- W2068617275 date "2010-01-01" @default.
- W2068617275 modified "2023-10-03" @default.
- W2068617275 title "Understanding the in vitro neuromuscular activity of snake venom Lys49 phospholipase A2 homologues" @default.
- W2068617275 cites W1487525039 @default.
- W2068617275 cites W1501888177 @default.
- W2068617275 cites W1526580466 @default.
- W2068617275 cites W1534485474 @default.
- W2068617275 cites W1557383518 @default.
- W2068617275 cites W1563705922 @default.
- W2068617275 cites W1577981179 @default.
- W2068617275 cites W1934159923 @default.
- W2068617275 cites W1964170820 @default.
- W2068617275 cites W1964748161 @default.
- W2068617275 cites W1964814810 @default.
- W2068617275 cites W1969308562 @default.
- W2068617275 cites W1970554441 @default.
- W2068617275 cites W1970838759 @default.
- W2068617275 cites W1971699336 @default.
- W2068617275 cites W1971734034 @default.
- W2068617275 cites W1972955194 @default.
- W2068617275 cites W1974960459 @default.
- W2068617275 cites W1975269273 @default.
- W2068617275 cites W1976813733 @default.
- W2068617275 cites W1981825623 @default.
- W2068617275 cites W1984084088 @default.
- W2068617275 cites W1985398501 @default.
- W2068617275 cites W1985713207 @default.
- W2068617275 cites W1987993631 @default.
- W2068617275 cites W1990799654 @default.
- W2068617275 cites W1993035495 @default.
- W2068617275 cites W1996116819 @default.
- W2068617275 cites W1997051679 @default.
- W2068617275 cites W1998144231 @default.
- W2068617275 cites W2001616870 @default.
- W2068617275 cites W2004614023 @default.
- W2068617275 cites W2006287346 @default.
- W2068617275 cites W2006589063 @default.
- W2068617275 cites W2013732980 @default.
- W2068617275 cites W2014620003 @default.
- W2068617275 cites W2015988606 @default.
- W2068617275 cites W2016008242 @default.
- W2068617275 cites W2019630454 @default.
- W2068617275 cites W2019935438 @default.
- W2068617275 cites W2022756220 @default.
- W2068617275 cites W2025650668 @default.
- W2068617275 cites W2030046736 @default.
- W2068617275 cites W2030742602 @default.
- W2068617275 cites W2031002978 @default.
- W2068617275 cites W2032798153 @default.
- W2068617275 cites W2033076090 @default.
- W2068617275 cites W2034433438 @default.
- W2068617275 cites W2036408863 @default.
- W2068617275 cites W2037389021 @default.
- W2068617275 cites W2039776683 @default.
- W2068617275 cites W2040170805 @default.
- W2068617275 cites W2040600113 @default.
- W2068617275 cites W2041541030 @default.
- W2068617275 cites W2045050749 @default.
- W2068617275 cites W2045114420 @default.
- W2068617275 cites W2050803340 @default.
- W2068617275 cites W2051018818 @default.
- W2068617275 cites W2051952693 @default.
- W2068617275 cites W2053812662 @default.
- W2068617275 cites W2053821558 @default.
- W2068617275 cites W2054341690 @default.
- W2068617275 cites W2057403631 @default.
- W2068617275 cites W2062685941 @default.
- W2068617275 cites W2067629117 @default.
- W2068617275 cites W2068672794 @default.
- W2068617275 cites W2071838869 @default.
- W2068617275 cites W2071876927 @default.
- W2068617275 cites W2073253218 @default.
- W2068617275 cites W2074826145 @default.
- W2068617275 cites W2075298528 @default.
- W2068617275 cites W2075347510 @default.
- W2068617275 cites W2077534140 @default.
- W2068617275 cites W2078660762 @default.
- W2068617275 cites W2078681809 @default.
- W2068617275 cites W2080550444 @default.
- W2068617275 cites W2081404276 @default.
- W2068617275 cites W2085232594 @default.
- W2068617275 cites W2087874171 @default.
- W2068617275 cites W2089332600 @default.
- W2068617275 cites W2092340365 @default.
- W2068617275 cites W2094451213 @default.
- W2068617275 cites W2096774625 @default.
- W2068617275 cites W2097196929 @default.
- W2068617275 cites W2099718704 @default.
- W2068617275 cites W2099925238 @default.
- W2068617275 cites W2100631820 @default.
- W2068617275 cites W2106081526 @default.
- W2068617275 cites W2109541097 @default.
- W2068617275 cites W2112827912 @default.
- W2068617275 cites W2115564500 @default.