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- W2068628503 abstract "Monodisperse populations of lipid-coated microbubbles were produced using a flow-focusing microfluidic device. The microbubbles were formed by forcing a lipid solution and perfluorocarbon gas through a narrow orifice simultaneously. The average bubble size depended on the lipid solution flow rate, the gas pressure, and the size of the inlet microchannels and narrow orifice. We have successfully produced monodispersions of microbubbles with average diameters ranging from 4–11 μm. Monodisperse bubble populations were suspended in an exposure vessel, and the attenuation coefficient between 1–7.5 MHz was measured using an acoustic spectroscopy method. The frequency at which the peak attenuation coefficient was measured was dependent on the mean bubble diameter. For example, microbubbles with diameters of 4 and 8 μm had peak attenuation coefficients at approximately 3.0 and 1.5 MHz, respectively. Additionally, it was noted that the bandwidth of the frequency-dependent attenuation coefficients was wider for polydisperse populations compared to monodisperse populations of lipid-coated microbubbles. Implications of these results on the acoustic characterization and use of monodispersions of lipid-coated microbubbles for molecular imaging will be discussed." @default.
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- W2068628503 date "2009-10-01" @default.
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- W2068628503 title "An in vitro study of the relationship between the size of lipid-coated microbubbles and frequency-dependent attenuation coefficient." @default.
- W2068628503 doi "https://doi.org/10.1121/1.3248486" @default.
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