FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068631477> ?p ?o ?g. }

• W2068631477 endingPage "1075" @default.
• W2068631477 startingPage "1069" @default.
• W2068631477 abstract "Auriculin is a potent vasoactive and natriuretic peptide that was recently isolated and purified from rat atrial tissue. Since this peptide could be of great importance for renal, cardiovascular, and volume homeostasis, its functional properties have been characterized in dogs. The effects of synthetic auriculin on renal function, mean blood pressure, plasma renin activity, renin secretory rate, and plasma aldosterone levels were determined. Auriculin was administered intravenously as a prime (1.0 microgram/kg body weight) and constant infusion (0.1 microgram per minute/kg body weight for one hour) to five anesthetized dogs. In addition, two conscious dogs were used to verify some of the results obtained in anesthetized dogs. Auriculin decreased mean blood pressure from 134 +/- 5 to 122 +/- 4 mm Hg (p less than 0.05, paired t test) and increased glomerular filtration rate (25.5 +/- 2.7 to 32.4 +/- 4.1 ml per minute per kidney, p less than 0.05), diuresis (0.21 +/- 0.03 to 1.06 +/- 0.14 ml per minute per kidney, p less than 0.05), natriuresis (38 +/- 0.6 to 187 +/- 35 mueq per minute per kidney, p less than 0.05), and kaliuresis (14.8 +/- 1.6 to 35.7 +/- 6.3 mueq per minute per kidney, p less than 0.05). These effects were sustained throughout the infusion of auriculin and were entirely reversible. Renal plasma flow increased transiently for one to two minutes, and then returned to or below control levels. Urine osmolality decreased by 40 percent (p less than 0.05) whereas free water clearance remained unchanged (p less than 0.05). Auriculin reversibly decreased plasma renin activity (11.6 +/- 2.3 to 3.6 +/- 1.2 ng/ml per hour, p less than 0.05), renin secretory rate (895 +/- 313 to 255 +/- 28 ng per hour per minute, p less than 0.05), and plasma aldosterone levels (8.4 +/- 1.6 to 3.6 +/- 0.7 ng/dl, p less than 0.05), whereas plasma cortisol levels remained unchanged. These results demonstrate that auriculin has a unique combination of functional properties, increasing glomerular filtration rate, diuresis, and natriuresis, without a sustained increase in total renal blood flow, and lowering blood pressure, plasma renin levels, renin secretory rate, and plasma aldosterone levels. These properties suggest an important potential role for atrial natriuretic peptides in the regulation of renal function, extracellular volume, and blood pressure." @default.
• W2068631477 created "2016-06-24" @default.
• W2068631477 creator A5006936798 @default.
• W2068631477 creator A5025665424 @default.
• W2068631477 creator A5035909731 @default.
• W2068631477 creator A5047363033 @default.
• W2068631477 creator A5055533470 @default.
• W2068631477 creator A5076743084 @default.
• W2068631477 creator A5088208349 @default.
• W2068631477 date "1984-12-01" @default.
• W2068631477 modified "2023-10-15" @default.
• W2068631477 title "Effects of auriculin (atrial natriuretic factor) on blood pressure, renal function, and the renin-aldosterone system in dogs" @default.
• W2068631477 cites W1964404358 @default.
• W2068631477 cites W1978411785 @default.
• W2068631477 cites W1994684915 @default.
• W2068631477 cites W1998089737 @default.
• W2068631477 cites W2005257617 @default.
• W2068631477 cites W2021642938 @default.
• W2068631477 cites W2023758236 @default.
• W2068631477 cites W2024494699 @default.
• W2068631477 cites W2025714870 @default.
• W2068631477 cites W2034376730 @default.
• W2068631477 cites W2052097767 @default.
• W2068631477 cites W2059787491 @default.
• W2068631477 cites W2075507006 @default.
• W2068631477 cites W2092505871 @default.
• W2068631477 cites W2092885332 @default.
• W2068631477 cites W2111095103 @default.
• W2068631477 cites W2413383566 @default.
• W2068631477 doi "https://doi.org/10.1016/0002-9343(84)90190-6" @default.
• W2068631477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6239544" @default.
• W2068631477 hasPublicationYear "1984" @default.
• W2068631477 type Work @default.
• W2068631477 sameAs 2068631477 @default.
• W2068631477 citedByCount "511" @default.
• W2068631477 countsByYear W20686314772012 @default.
• W2068631477 countsByYear W20686314772013 @default.
• W2068631477 countsByYear W20686314772014 @default.
• W2068631477 countsByYear W20686314772015 @default.
• W2068631477 countsByYear W20686314772018 @default.
• W2068631477 countsByYear W20686314772019 @default.
• W2068631477 countsByYear W20686314772022 @default.
• W2068631477 crossrefType "journal-article" @default.
• W2068631477 hasAuthorship W2068631477A5006936798 @default.
• W2068631477 hasAuthorship W2068631477A5025665424 @default.
• W2068631477 hasAuthorship W2068631477A5035909731 @default.
• W2068631477 hasAuthorship W2068631477A5047363033 @default.
• W2068631477 hasAuthorship W2068631477A5055533470 @default.
• W2068631477 hasAuthorship W2068631477A5076743084 @default.
• W2068631477 hasAuthorship W2068631477A5088208349 @default.
• W2068631477 hasConcept C126322002 @default.
• W2068631477 hasConcept C134018914 @default.
• W2068631477 hasConcept C138976137 @default.
• W2068631477 hasConcept C142225936 @default.
• W2068631477 hasConcept C159641895 @default.
• W2068631477 hasConcept C174459258 @default.
• W2068631477 hasConcept C198710026 @default.
• W2068631477 hasConcept C21652263 @default.
• W2068631477 hasConcept C2778069365 @default.
• W2068631477 hasConcept C2778525890 @default.
• W2068631477 hasConcept C2779547328 @default.
• W2068631477 hasConcept C2780011235 @default.
• W2068631477 hasConcept C2780091579 @default.
• W2068631477 hasConcept C71924100 @default.
• W2068631477 hasConcept C84393581 @default.
• W2068631477 hasConceptScore W2068631477C126322002 @default.
• W2068631477 hasConceptScore W2068631477C134018914 @default.
• W2068631477 hasConceptScore W2068631477C138976137 @default.
• W2068631477 hasConceptScore W2068631477C142225936 @default.
• W2068631477 hasConceptScore W2068631477C159641895 @default.
• W2068631477 hasConceptScore W2068631477C174459258 @default.
• W2068631477 hasConceptScore W2068631477C198710026 @default.
• W2068631477 hasConceptScore W2068631477C21652263 @default.
• W2068631477 hasConceptScore W2068631477C2778069365 @default.
• W2068631477 hasConceptScore W2068631477C2778525890 @default.
• W2068631477 hasConceptScore W2068631477C2779547328 @default.
• W2068631477 hasConceptScore W2068631477C2780011235 @default.
• W2068631477 hasConceptScore W2068631477C2780091579 @default.
• W2068631477 hasConceptScore W2068631477C71924100 @default.
• W2068631477 hasConceptScore W2068631477C84393581 @default.
• W2068631477 hasIssue "6" @default.
• W2068631477 hasLocation W20686314771 @default.
• W2068631477 hasLocation W20686314772 @default.
• W2068631477 hasOpenAccess W2068631477 @default.
• W2068631477 hasPrimaryLocation W20686314771 @default.
• W2068631477 hasRelatedWork W2032927426 @default.
• W2068631477 hasRelatedWork W2043883559 @default.
• W2068631477 hasRelatedWork W2051540011 @default.
• W2068631477 hasRelatedWork W2067451005 @default.
• W2068631477 hasRelatedWork W2072039023 @default.
• W2068631477 hasRelatedWork W2103788696 @default.
• W2068631477 hasRelatedWork W2132717108 @default.
• W2068631477 hasRelatedWork W2170946197 @default.
• W2068631477 hasRelatedWork W2242866720 @default.
• W2068631477 hasRelatedWork W2887452857 @default.
• W2068631477 hasVolume "77" @default.
• W2068631477 isParatext "false" @default.
• W2068631477 isRetracted "false" @default.

• next