Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068637095> ?p ?o ?g. }
- W2068637095 endingPage "617" @default.
- W2068637095 startingPage "609" @default.
- W2068637095 abstract "The liquid chromatography–mass spectrometry (LC–MS) methods were developed and validated for the determination of testosterone (T) in the brain and serum of rats and of 5α-androstane-3α,17β-diol (ADIOL), a metabolite of T, in the brain of rats. After derivatization of T with 2-hydrazino-1-methylpyridine and of ADIOL with p-nitrobenzoyl chloride, the detection sensitivities of T and ADIOL using LC–MS were increased 70- and 400-times superior to those of intact T and intact ADIOL, respectively. Those LC–MS methods are specific and reliable for the analysis of trace amounts of T and ADIOL in small amounts of samples. The animal studies using the developed methods showed that the brain and serum levels of T and the brain levels of ADIOL were not changed by stress or ethanol administration but the concentration ratio of the brain T to serum T in the stressed rats was higher than that in untreated rats. The low levels of endogenous AIDOL in brain of stressed and unrestrained rats found in this study demonstrated that the contribution to anesthetic and anxiolytic effects of ADIOL via γ-aminobutyric acid type A receptors may be negligible." @default.
- W2068637095 created "2016-06-24" @default.
- W2068637095 creator A5006215637 @default.
- W2068637095 creator A5033392956 @default.
- W2068637095 creator A5038180015 @default.
- W2068637095 creator A5049549243 @default.
- W2068637095 creator A5050553042 @default.
- W2068637095 creator A5035227114 @default.
- W2068637095 date "2006-07-01" @default.
- W2068637095 modified "2023-10-05" @default.
- W2068637095 title "Studies on neurosteroids XVIII" @default.
- W2068637095 cites W1484579537 @default.
- W2068637095 cites W162491450 @default.
- W2068637095 cites W1968427184 @default.
- W2068637095 cites W1974556160 @default.
- W2068637095 cites W1985705387 @default.
- W2068637095 cites W2002862204 @default.
- W2068637095 cites W2014668639 @default.
- W2068637095 cites W2015334615 @default.
- W2068637095 cites W2024344189 @default.
- W2068637095 cites W2025645923 @default.
- W2068637095 cites W2026103850 @default.
- W2068637095 cites W2031500928 @default.
- W2068637095 cites W2032260926 @default.
- W2068637095 cites W2036671886 @default.
- W2068637095 cites W2047930498 @default.
- W2068637095 cites W2056553199 @default.
- W2068637095 cites W2081784418 @default.
- W2068637095 cites W2084243951 @default.
- W2068637095 cites W2136711899 @default.
- W2068637095 cites W2146694611 @default.
- W2068637095 cites W2152712199 @default.
- W2068637095 cites W2155781104 @default.
- W2068637095 doi "https://doi.org/10.1016/j.steroids.2006.03.003" @default.
- W2068637095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16620893" @default.
- W2068637095 hasPublicationYear "2006" @default.
- W2068637095 type Work @default.
- W2068637095 sameAs 2068637095 @default.
- W2068637095 citedByCount "30" @default.
- W2068637095 countsByYear W20686370952013 @default.
- W2068637095 countsByYear W20686370952014 @default.
- W2068637095 countsByYear W20686370952017 @default.
- W2068637095 countsByYear W20686370952018 @default.
- W2068637095 countsByYear W20686370952020 @default.
- W2068637095 countsByYear W20686370952023 @default.
- W2068637095 crossrefType "journal-article" @default.
- W2068637095 hasAuthorship W2068637095A5006215637 @default.
- W2068637095 hasAuthorship W2068637095A5033392956 @default.
- W2068637095 hasAuthorship W2068637095A5035227114 @default.
- W2068637095 hasAuthorship W2068637095A5038180015 @default.
- W2068637095 hasAuthorship W2068637095A5049549243 @default.
- W2068637095 hasAuthorship W2068637095A5050553042 @default.
- W2068637095 hasConcept C126322002 @default.
- W2068637095 hasConcept C134018914 @default.
- W2068637095 hasConcept C162356407 @default.
- W2068637095 hasConcept C16613235 @default.
- W2068637095 hasConcept C168258287 @default.
- W2068637095 hasConcept C170493617 @default.
- W2068637095 hasConcept C185592680 @default.
- W2068637095 hasConcept C2776923573 @default.
- W2068637095 hasConcept C2777477808 @default.
- W2068637095 hasConcept C2777765862 @default.
- W2068637095 hasConcept C2779279991 @default.
- W2068637095 hasConcept C43617362 @default.
- W2068637095 hasConcept C44796713 @default.
- W2068637095 hasConcept C55493867 @default.
- W2068637095 hasConcept C71924100 @default.
- W2068637095 hasConcept C86803240 @default.
- W2068637095 hasConceptScore W2068637095C126322002 @default.
- W2068637095 hasConceptScore W2068637095C134018914 @default.
- W2068637095 hasConceptScore W2068637095C162356407 @default.
- W2068637095 hasConceptScore W2068637095C16613235 @default.
- W2068637095 hasConceptScore W2068637095C168258287 @default.
- W2068637095 hasConceptScore W2068637095C170493617 @default.
- W2068637095 hasConceptScore W2068637095C185592680 @default.
- W2068637095 hasConceptScore W2068637095C2776923573 @default.
- W2068637095 hasConceptScore W2068637095C2777477808 @default.
- W2068637095 hasConceptScore W2068637095C2777765862 @default.
- W2068637095 hasConceptScore W2068637095C2779279991 @default.
- W2068637095 hasConceptScore W2068637095C43617362 @default.
- W2068637095 hasConceptScore W2068637095C44796713 @default.
- W2068637095 hasConceptScore W2068637095C55493867 @default.
- W2068637095 hasConceptScore W2068637095C71924100 @default.
- W2068637095 hasConceptScore W2068637095C86803240 @default.
- W2068637095 hasIssue "7" @default.
- W2068637095 hasLocation W20686370951 @default.
- W2068637095 hasLocation W20686370952 @default.
- W2068637095 hasOpenAccess W2068637095 @default.
- W2068637095 hasPrimaryLocation W20686370951 @default.
- W2068637095 hasRelatedWork W1970739379 @default.
- W2068637095 hasRelatedWork W1988486434 @default.
- W2068637095 hasRelatedWork W1998113603 @default.
- W2068637095 hasRelatedWork W1999611386 @default.
- W2068637095 hasRelatedWork W1999831221 @default.
- W2068637095 hasRelatedWork W2027237635 @default.
- W2068637095 hasRelatedWork W2027748287 @default.
- W2068637095 hasRelatedWork W2036308844 @default.
- W2068637095 hasRelatedWork W2081677525 @default.