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• W2068637259 abstract "(-)-Phenylahistin, a fungal diketopiperazine metabolite composed of phenylalanine and isoprenylated dehydrohistidine, arrested cells in mitosis and inhibited the proliferation of A549 cells. The microtubule network in A549 cells was disrupted by (-)-phenylahistin, which also inhibited the polymerization of both microtubule protein from bovine brain and phosphocellulose-purified tubulin in vitro. Competitive binding studies indicated that (-)-phenylahistin interacted with the colchicine binding site on tubulin but not with the vinblastine binding site." @default.
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• W2068637259 date "1999-01-01" @default.
• W2068637259 modified "2023-10-01" @default.
• W2068637259 title "(-)-Phenylahistin Arrests Cells in Mitosis by Inhibiting Tubulin Polymerization." @default.
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• W2068637259 doi "https://doi.org/10.7164/antibiotics.52.134" @default.
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