Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068644125> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2068644125 abstract "Gender differences may significantly influence the toxicity of cocaine in mammals. In this study, the influence of gender on the toxicity of norcocaine, a pharmacologically active metabolite of cocaine, was compared with its parent compound in adult male and female rats. In addition, the plasma and tissue norcocaine concentrations were evaluated after the administration of norcocaine and cocaine. Norcocaine or cocaine was administered intravenously at a rate of 2 mg/kg/min until circulatory collapse. Arterial blood samples as well as heart, liver, and brain tissues were obtained at circulatory collapse for the measurement of concentrations of norcocaine as well as cocaine and its major metabolites. There were no gender-related differences in the doses of norcocaine required to produce circulatory collapse; however, there were significant gender-related differences in the norcocaine tissue-to-plasma concentration ratios (T:P ratios). After the administration of norcocaine, T:P ratios for heart, liver, and brain tissue were significantly greater in males. Furthermore, after cocaine administration, the hepatic norcocaine T:P ratio was approximately 3-fold greater in the male rats than in the female rats. In contrast, female rats had a greater percentage of norcocaine in the plasma at circulatory collapse after acute cocaine administration. Although no gender differences in the lethality of norcocaine were observed, it remains to be seen whether the gender differences in the distribution and uptake of norcocaine play a role in the hepatotoxicity of the drug, particularly after chronic exposure." @default.
- W2068644125 created "2016-06-24" @default.
- W2068644125 creator A5005172539 @default.
- W2068644125 creator A5021095739 @default.
- W2068644125 creator A5030014983 @default.
- W2068644125 creator A5063655189 @default.
- W2068644125 creator A5089149338 @default.
- W2068644125 date "1999-06-01" @default.
- W2068644125 modified "2023-09-25" @default.
- W2068644125 title "Role of gender in the toxicity of norcocaine" @default.
- W2068644125 cites W1610318800 @default.
- W2068644125 cites W1932666659 @default.
- W2068644125 cites W1945438459 @default.
- W2068644125 cites W1988024459 @default.
- W2068644125 cites W1989740023 @default.
- W2068644125 cites W1999603496 @default.
- W2068644125 cites W2016373232 @default.
- W2068644125 cites W2030449743 @default.
- W2068644125 cites W2031639051 @default.
- W2068644125 cites W2039946561 @default.
- W2068644125 cites W2041070835 @default.
- W2068644125 cites W2046828540 @default.
- W2068644125 cites W2067865899 @default.
- W2068644125 cites W2088133477 @default.
- W2068644125 cites W2120152079 @default.
- W2068644125 cites W2122082133 @default.
- W2068644125 cites W2154908498 @default.
- W2068644125 cites W2407968248 @default.
- W2068644125 cites W2410387798 @default.
- W2068644125 cites W270755921 @default.
- W2068644125 cites W1993372880 @default.
- W2068644125 doi "https://doi.org/10.1016/s0022-2143(99)90189-0" @default.
- W2068644125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10360634" @default.
- W2068644125 hasPublicationYear "1999" @default.
- W2068644125 type Work @default.
- W2068644125 sameAs 2068644125 @default.
- W2068644125 citedByCount "7" @default.
- W2068644125 crossrefType "journal-article" @default.
- W2068644125 hasAuthorship W2068644125A5005172539 @default.
- W2068644125 hasAuthorship W2068644125A5021095739 @default.
- W2068644125 hasAuthorship W2068644125A5030014983 @default.
- W2068644125 hasAuthorship W2068644125A5063655189 @default.
- W2068644125 hasAuthorship W2068644125A5089149338 @default.
- W2068644125 hasConcept C126322002 @default.
- W2068644125 hasConcept C134018914 @default.
- W2068644125 hasConcept C2776371345 @default.
- W2068644125 hasConcept C2777477808 @default.
- W2068644125 hasConcept C29730261 @default.
- W2068644125 hasConcept C71924100 @default.
- W2068644125 hasConcept C72859922 @default.
- W2068644125 hasConcept C98274493 @default.
- W2068644125 hasConceptScore W2068644125C126322002 @default.
- W2068644125 hasConceptScore W2068644125C134018914 @default.
- W2068644125 hasConceptScore W2068644125C2776371345 @default.
- W2068644125 hasConceptScore W2068644125C2777477808 @default.
- W2068644125 hasConceptScore W2068644125C29730261 @default.
- W2068644125 hasConceptScore W2068644125C71924100 @default.
- W2068644125 hasConceptScore W2068644125C72859922 @default.
- W2068644125 hasConceptScore W2068644125C98274493 @default.
- W2068644125 hasLocation W20686441251 @default.
- W2068644125 hasLocation W20686441252 @default.
- W2068644125 hasOpenAccess W2068644125 @default.
- W2068644125 hasPrimaryLocation W20686441251 @default.
- W2068644125 hasRelatedWork W1965018572 @default.
- W2068644125 hasRelatedWork W1971955975 @default.
- W2068644125 hasRelatedWork W1980504779 @default.
- W2068644125 hasRelatedWork W2015471759 @default.
- W2068644125 hasRelatedWork W2018747101 @default.
- W2068644125 hasRelatedWork W2058036839 @default.
- W2068644125 hasRelatedWork W2062600851 @default.
- W2068644125 hasRelatedWork W2112727823 @default.
- W2068644125 hasRelatedWork W2122175444 @default.
- W2068644125 hasRelatedWork W2785926487 @default.
- W2068644125 isParatext "false" @default.
- W2068644125 isRetracted "false" @default.
- W2068644125 magId "2068644125" @default.
- W2068644125 workType "article" @default.