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• W2068644391 abstract "Abstract: The subcutaneous injection of isoprenaline, salbutamol, histamine, and adrenaline to rats, which were subsequently killed by microwave irradiation, resulted in a rapid increase in the cyclic AMP content of the carotid body. On the other hand, noradrenaline, dopamine, adenosine, and 5-hydroxytryptamine, at doses at least 100 times greater than that of isoprenaline, did not significantly alter the cyclic nucleotide content in vivo. The response to isoprenaline was dose related, with an ED50 of 15 μg · kg−1, and reached a peak level 1–1.5 min after injection. Incubation of intact carotid bodies with isoprenaline (10-−5M)in vitro also resulted in a 10-fold increase in cyclic AMP content. The in vivo response to isoprenaline could be blocked stereo-selectively by propranolol, and ICI 118.551, a β2-selective antagonist, blocks the isoprenaline-elicited increase in cyclic AMP completely at a dose of 30 μg · kg−1; whereas betaxolol, a β1-selective antagonist, was ineffective, even at a dose of 300 μg · kg−1. Hypoxia (5% oxygen in 95% N2) did not result in a significant increase in the cyclic AMP content, nor did it significantly alter the isoprenaline-stimulated increase in the cyclic AMP content of the rat carotid body. These results suggest that some catecholamines may stimulate cyclic AMP formation by interacting with a β2-adrenoceptor in the rat carotid body." @default.
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• W2068644391 date "1983-09-01" @default.
• W2068644391 modified "2023-09-30" @default.
• W2068644391 title "Biogenic Amine-Stimulated Cyclic Adenosine-3',5'-Monophosphate Formation in the Rat Carotid Body" @default.
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• W2068644391 doi "https://doi.org/10.1111/j.1471-4159.1983.tb04792.x" @default.
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